Heart Regeneration by Endogenous Stem Cells and Cardiomyocyte Proliferation: Controversy, Fallacy, and Progress.

Circulation
Lingjuan HeBin Zhou

Abstract

Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and heart failure. Identifying new sources for cardiomyocytes and promoting their formation represents a goal of cardiac biology and regenerative medicine. Within the past decade, many types of putative cardiac stem cells (CSCs) have been reported to regenerate the injured myocardium by differentiating into new cardiomyocytes. Some of these CSCs have been translated from bench to bed with reported therapeutic effectiveness. However, recent basic research studies on stem cell tracing have begun to question their fundamental biology and mechanisms of action, raising serious concerns over the myogenic potential of CSCs. We review the history of different types of CSCs within the past decade and provide an update of recent cell tracing studies that have challenged the origin and existence of CSCs. In addition to the potential role of CSCs in heart regeneration, proliferation of preexisting cardiomyocytes has recently gained more attention. This review will also evaluate the methodologic and technical aspects of past and current studies on CSCs and cardiomyocyte pr...Continue Reading

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Citations

Oct 22, 2020·International Journal of Molecular Sciences·Antonia MancusoDonatella Paolino
Nov 27, 2020·Cardiovascular Research·Judy R Sayers, Paul R Riley
Jan 26, 2021·Stem Cell Reviews and Reports·Deepa BhartiyaSubhan Ali Mohammad
Nov 17, 2020·Frontiers in Genetics·Sushmitha DudduPraphulla Chandra Shukla
Feb 16, 2021·Physiological Reports·Ying-Chang HsuehJose A Gomez
Dec 19, 2020·Current Opinion in Pharmacology·Nino ChiricoPieterjan Dierickx
May 29, 2021·Frontiers in Cell and Developmental Biology·Stefan EldeY Joseph Woo
Jun 8, 2021·Frontiers in Cardiovascular Medicine·Atze van der Pol, Carlijn V C Bouten
Jun 22, 2021·European Heart Journal·Bernardo Nadal-GinardDaniele Torella
Oct 2, 2021·Communications Biology·Mariangela ScaliseEleonora Cianflone
Jun 2, 2021·Cell Regeneration·Zhaohui Ouyang, Ke Wei
Aug 31, 2021·Current Opinion in Cardiology·Veronika SedlakovaEmilio I Alarcon

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