Heart remodeling produced by aortic stenosis promotes cardiomyocyte apoptosis mediated by collagen V imbalance

Pathophysiology : the Official Journal of the International Society for Pathophysiology
Paula Grippa Sant'AnaAlexandre Todorovic Fabro

Abstract

Cardiac remodeling (CR) is a structural change of the heart due to chronic hemodynamic overload related to changes in both myocyte and extracellular matrix (ECM). We investigated that the imbalance of collagen V promotes cardiomyocyte apoptosis that contributes to heart failure and cell death. Aortic stenosis was induced surgically and male Wistar rats were randomized to 18 weeks (Sham 18 w, n = 12; AoS 18 w, n = 12) and severe of heart failure (Sham HF, n = 12; AoS HF, n = 12) groups. Functional and structural echocardiogram, immunohistochemistry for Ki-67, TUNEL assay and Immunofluorescence for collagen were performed. Our main results were: (1) Progressive reduction of cardiac functional capacity due to cardiac remodeling with decreased eject fraction in heart failure; (2) Imbalance of collagen deposition with increased, crowded and irregular collagen I in situ expression; (3) Dysregulation of dynamic control of collagen fibers with exposed epitopes of collagen V; (4) Additional apoptosis that are dependent to cardiac injury. The collagen V expression in cardiac remodeling is for the first time described and may be related to additional apoptosis and autoimmune response. Our findings suggest a critical role of collagen V in ...Continue Reading

Citations

Jun 21, 2019·Circulation Research·Nikolaos G Frangogiannis
Jun 27, 2019·Acta Veterinaria Hungarica·Laís L FernandesCarlos R Teixeira
Apr 5, 2020·Journal of Cardiovascular Translational Research·Sérgio Luiz Borges de SouzaAndré Ferreira do Nascimento
Nov 23, 2020·Archives of Medical Research·Cristina Schmitt GregolinAndré Ferreira do Nascimento
Oct 26, 2020·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Sabrina Setembre BatahAlexandre Todorovic Fabro

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