Heart team approach in treatment of mitral regurgitation: patient selection and outcome

Open Heart
Mischa KüllingPatric Biaggi

Abstract

A multidisciplinary heart valve team is recommended for the evaluation of treatment in patients with valvular heart disease, but evidence supporting this concept is lacking. In patients with severe mitral regurgitation, we thought to analyse the patient selection process by the heart team for different treatment options and the outcome after treatment. In this single-centre cohort study, all patients treated for mitral regurgitation between July 2013 and September 2018 were included. Primary end points during follow-up were all-cause mortality and a combined end point, consisting of all-cause mortality, cardiovascular rehospitalisation and mitral valve reintervention. 179 patients (44.8%) were treated using Mitraclip, 185 (46.2%) by surgical repair and 36 (9.0%) by surgical replacement. The mortality risk according to EuroScore II differed significantly between treatment groups (6.6%±5.6%, 1.7%±1.5% and 3.6%±2.7% for Mitraclip, surgical repair and replacement, respectively, p<0.001). In-hospital mortality for the 3 groups were 3.4%, 1.6% and 8.3%, respectively (p=0.091). Overall, surgical repair patients had higher 4-year survival (HR 0.40 (95% CI 0.26 to 0.63), p<0.001) and fewer combined end points (HR 0.51 (95% CI 0.32 to 0....Continue Reading

References

Nov 26, 2010·The Annals of Thoracic Surgery·Steven F BollingJames S Gammie
Apr 6, 2011·The New England Journal of Medicine·Ted FeldmanUNKNOWN EVEREST II Investigators
Apr 28, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Patric BiaggiAnna Woo
Jun 16, 2012·The Journal of Thoracic and Cardiovascular Surgery·Javier G CastilloDavid H Adams
Mar 2, 2013·Journal of the American College of Cardiology·David R HolmesMichael J Mack
Jun 5, 2013·European Heart Journal Cardiovascular Imaging·Patrizio LancellottiUNKNOWN Scientific Document Committee of the European Association of Cardiovascular Imaging
Aug 26, 2014·JACC. Cardiovascular Interventions·Martin J SwaansJan A S Van der Heyden
Nov 10, 2015·The New England Journal of Medicine·Daniel GoldsteinUNKNOWN CTSN
Jan 1, 2016·Journal of the American College of Cardiology·Ted FeldmanUNKNOWN EVEREST II Investigators
Aug 26, 2017·Journal of the American College of Cardiology·Sung-Han YoonRaj R Makkar
Sep 10, 2017·European Heart Journal·Helmut BaumgartnerUNKNOWN ESC Scientific Document Group
Feb 12, 2019·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·S HeutsP Sardari Nia
Feb 25, 2019·The Journal of Thoracic and Cardiovascular Surgery·Nicola BuzzattiOttavio Alfieri
Mar 23, 2019·Journal of the American College of Cardiology·Paul SorajjaDavid Muller
Aug 24, 2019·Journal of the American Heart Association·David Del ValJosep Rodés-Cabau
Dec 24, 2019·The Annals of Thoracic Surgery·Tyler J BeuteCharles L Willekes
Jan 27, 2020·The American Journal of Cardiology·Aaqib H MalikGilbert H L Tang

❮ Previous
Next ❯

Citations

Mar 16, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Hugo-Pierre RacineFrançois Philippon

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary bypass

Software Mentioned

R
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of the Academy of Medicine, Singapore
Ningyan WongKhung Keong Yeo
Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Paolo FerraroArturo Giordano
© 2021 Meta ULC. All rights reserved