Heart Transplant Survival Based on Recipient and Donor Risk Scoring: A UNOS Database Analysis

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Jaimin R TrivediMark S Slaughter

Abstract

Unlike the lung allocation score, currently, there is no quantitative scoring system available for patients on heart transplant waiting list. By using United Network for Organ Sharing (UNOS) data, we aim to generate a scoring system based on the recipient and donor risk factors to predict posttransplant survival. Available UNOS data were queried between 2005 and 2013 for heart transplant recipients aged ≥18 years to create separate cox-proportional hazard models for recipient and donor risk scoring. On the basis of risk scores, recipients were divided into five groups and donors into three groups. Kaplan-Meier curves were used for survival. Total 17,131 patients had heart transplant within specified time period. Major factors within high-risk groups were body mass index > 30 kg/m (46%), mean pulmonary artery pressure >30 mmHg (65%), creatinine > 1.5 mg% (63%), bilirubin > 1.5 mg% (54%), noncontinuous-flow left ventricular assist devices (45%) for recipients and gender mismatch (81%) and ischemia time >4 hours (88%) for donors. Survival in recipient groups 1, 2, 3, 4, and 5 at 5 years was 81, 80, 77, 74, and 62%, respectively, and in donor groups 1, 2, and 3 at 5 years was 79, 77, and 70%, respectively (p < 0.001). Combining don...Continue Reading

References

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Citations

Dec 13, 2016·The Annals of Thoracic Surgery·Jaimin R TrivediMark S Slaughter
Apr 1, 2017·Journal of the American College of Cardiology·Vidang P NguyenTodd F Dardas
Oct 14, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Erin M SchumerMark S Slaughter
Dec 6, 2018·Current Opinion in Organ Transplantation·Paolo Cravedi
Jan 20, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Eileen M HsichUNKNOWN Transplantation of HEarts to MaxImize Survival (THEMIS) Investigators
Jun 17, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Lu WangNeil S Sheerin
Jul 28, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Guillaume CoutanceJignesh K Patel
Dec 7, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Carine JasseronRichard Dorent
Nov 17, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Natasha AleksovaJuan G Duero Posada
Feb 24, 2020·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Richard KirkWarren A Zuckerman
Jun 15, 2020·JACC. Heart Failure·Eileen M HsichHemant Ishwaran
Jul 19, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Guillaume CoutanceJignesh K Patel
Jul 29, 2021·Clinical Transplantation·Ross M ReulAbbas A Rana
Sep 25, 2021·Journal of Cardiac Surgery·Nicholas R Hess, Arman Kilic
Sep 25, 2021·Journal of Cardiac Surgery·Antonio PiperataTomaso Bottio
Sep 29, 2021·The Annals of Thoracic Surgery·Dhaval ChauhanSuyog Mokashi

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