Heart transplantation--an update

Clinical Cardiology
A Blum, D Aravot

Abstract

Cardiologists caring for heart transplant recipients must be familiar with the pharmacology, drug interactions, and drug toxicity of those agents used extensively in clinical practice (cyclosporine, prednisone, azathioprine, polyclonal and monoclonal anti-T-cell agents) and the newer treatments [methotrexate, FK-506, rapamycin, mycophenolate mofetil (RS61443), deoxyspergualin, anti-CD4 monoclonal antibodies, total lymphoid irradiation, and photophoresis]. Another important aspect of medical follow-up is the detection, differential diagnosis, and treatment of allograft dysfunction. Hemodynamic abnormalities that occur as a result of rejection or a direct drug effect must be differentiated from physiologic changes. Cardiac allograft vasculopathy is the primary impediment to the long-term survival of heart transplant recipients. Immunopathogenesis, prevention, early detection, and treatment of allograft vasculopathy should be the major focus of heart transplantation research.

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Citations

Aug 26, 1998·Journal of Cardiothoracic and Vascular Anesthesia·L M MontenegroP J Davis
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C BuchananF Shihab
Dec 30, 2015·North American Journal of Medical Sciences·Chetana ShenoyGururaja K Rao
Oct 24, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Leslie W Miller
Sep 18, 2020·European Heart Journal. Cardiovascular Pharmacotherapy·Seif El HadidiAndrew J S Coats

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