PMID: 9441155Jan 24, 1998Paper

Heart transplantation--state of the art today

Herz
B M MeiserB Reichart

Abstract

In spite of pharmacological progress, end stage congestive heart failure is still associated with a decrease in quality and expectation of life. Heart transplantation remains the last therapeutic option for these patients. While the one year survival rate has increased over the last few years up to 84%, a major problem remains the significant lack of donors. Therefore, the criteria for the selection of candidates for cardiac transplantation have to be kept quite tight: Evidence of poor outcome without transplantation is associated with ejection fractions below 20 to 25%, cardiac indices less than 2.01/min/m2, left ventricular filling pressure above 20 mm Hg and a enddiastolic diameter of > 80 mm. There are, however, also quite important functional parameters indicating the need for heart transplantation, e.g. the maximal oxygene uptake being less than 10 ml/kg/min or below 50% of the age-appropriate value. Elevated pulmonary vascular resistance above 4 to 5 Wood units without a significant decrease during application of prostaglandin derivatives or inhalation of NO represents a contraindication for orthotopic heart transplantation; alternatively, a heterotopic transplantation can be considered. Since there is a significant shor...Continue Reading

References

Apr 1, 1992·Transplantation·M R Costanzo-NordinJ A Robinson
Nov 1, 1991·The Annals of Thoracic Surgery·G DreyfusA F Carpentier
May 1, 1991·American Heart Journal·W von ScheidtG Autenrieth
Jun 23, 1989·JAMA : the Journal of the American Medical Association·M T GrattanN E Shumway
Feb 5, 1987·The New England Journal of Medicine·R EdelsonG Plewig
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·H E von der LeyenV J Dzau
Sep 7, 1995·The New England Journal of Medicine·J A KobashigawaG A Cogert
Jul 1, 1995·Journal of the American College of Cardiology·A A HalleT R Aversano
Jan 1, 1995·Journal of the American College of Cardiology·L W StevensonD C Drinkwater
Apr 1, 1995·Journal of the American College of Cardiology·T G Di SalvoG W Dec
Jan 1, 1994·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·P MenaschéG Bloch
Sep 15, 1993·The American Journal of Cardiology·T H LeeJ A Walden
Jun 1, 1993·The Thoracic and Cardiovascular Surgeon·W von ScheidtE Erdmann
Jan 21, 1993·The New England Journal of Medicine·J S SchroederE B Stinson
Jul 1, 1993·Journal of the American College of Cardiology·J B YoungB F Uretsky
Apr 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·S M PhamB P Griffith
Mar 1, 1996·Current Opinion in Cardiology·L W Stevenson
Aug 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M SuthanthiranT B Strom
Aug 1, 1996·The American Journal of Physiology·W A Large, Q Wang

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