PMID: 9163590May 1, 1997Paper

Heart transplantation for end-stage heart failure caused by iron overload

British Journal of Haematology
M M KoernerR Koerfer

Abstract

Few reports exist concerning heart transplantation in recipients with end-stage myocardiopathy-associated heart failure caused by iron overload occurring with beta-thalassaemia, Diamond-Blackfan syndrome or haemochromatosis. Seven potential transplant candidates (six male, one female, mean age 26 years) with such heart failure, following desferrioxamine application subcutaneously over a number of years, and intravenously during their hospitalization before transplantation, were retrospectively analysed. Five were New York Heart Association (NYHA) class IV, three experienced one or more resuscitations immediately before transplantation could be performed. Continuous, high-volume, veno-venous haemofiltration was necessary in two patients. One of these two candidates additionally had to be bridged, first with a right ventricular, then with a biventricular assist device. Five of the seven patients survived, two with haemochromatosis, one with beta-thalassaemia major and one with Diamond-Blackfan syndrome following transplantation. One non-transplanted candidate with beta-thalassaemia major has been recompensated for 5 years. Survival was 14-74 months. Our results demonstrate the feasibility and indication of transplantation in pati...Continue Reading

Citations

Aug 19, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·A W DemantC Reichel
Jun 19, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R S SchofieldR Streiff
Jul 21, 1998·Annals of the New York Academy of Sciences·M Jessup, C S Manno
Aug 26, 1998·Annual Review of Nutrition·M A Beck, O A Levander
Sep 17, 2005·The American Journal of Medicine·George HahalisNicholas C Zoumbos
Feb 13, 2003·Pediatric Clinics of North America·Louise Lo, Sylvia Titi Singer
Mar 31, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Amitra E CainesAlexander S Geha
Mar 5, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Kulkarni VenugopalSuresh G Rao
Nov 16, 2011·Circulation·Dimitrios T Kremastinos, Dimitrios Farmakis
Jun 19, 2013·Circulation·Dudley J PennellUNKNOWN American Heart Association Committee on Heart Failure and Transplantation of the Council on Clinical Cardiology and Council
Apr 12, 2008·Journal of Cardiovascular Medicine·Tiziana CogliandroUNKNOWN Society for the Study of Thalassemia and Hemoglobinopathies (SoSTE)
Aug 22, 2000·Current Opinion in Cardiology·M M KoernerG Torre-Amione

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