Heart-type fatty acid binding protein and cardiac troponin I may have a diagnostic value in electrocution: A rat model

Journal of Forensic and Legal Medicine
Çağlar Özdemirİbrahim İkizceli

Abstract

Although cardiac injury is known to be the leading cause of death in electrocution, the differential diagnosis can be challenging in forensic practice since the exact mechanism is poorly understood and there is lack of reliable markers. Thus, death due to electrocution may be classified as a negative autopsy. The serum levels of and myocardial immunostaining loss for cardiac troponins and heart-type fatty acid binding protein (H-FABP) are highly sensitive and specific biomarkers of ischemic myocardial damage and may have a diagnostic value in determining the myocardial injury or the cause of death due to electrocution. Due to this reason, a rat model is prepared to investigate these issues. Thirty-two Wistar albino female rats were included and randomly divided into four groups of eight subjects. Group A was the control group, and Group B, C, and D were exposed to electrical current of 110 volt (V), 220 V, and 600 V, respectively. Blood samples and the hearts were collected from the rats for biochemical and immunostaining analyses. It is found that increased serum H-FABP levels were significantly associated with the higher voltage immediately after electrocution. However, serum cardiac troponin I (cTnI) levels did not show sign...Continue Reading

References

Jan 1, 1987·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·J P GuinardJ Freeman
Oct 24, 2001·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·S D Cohle, B A Sampson
Apr 10, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Michael C FishbeinFred S Apple
Nov 16, 2004·Forensic Science International : Synergy·Hannu KalimoDavid Graham
Sep 27, 2005·Forensic Science International : Synergy·Xiangzhi MengEnyin Wang
Jun 2, 2006·The American Journal of Forensic Medicine and Pathology·A Ben KhalifaT Mghirbi

❮ Previous
Next ❯

Citations

Jan 6, 2018·The Medico-legal Journal·Cristina MondelloElvira Ventura Spagnolo
May 9, 2021·Legal Medicine·Gennaro BaldinoElvira Ventura Spagnolo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.