Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis

Acta Pharmacologica Sinica
Xiao-Dong YeZhengyuan Xia

Abstract

Acute myocardial infarction (AMI) is a life-threatening event. Even with timely treatment, acute ischemic myocardial injury and ensuing ischemia reperfusion injury (IRI) can still be difficult issues to tackle. Apart from radiological and other auxiliary examinations, laboratory tests of applicable cardiac biomarkers are also necessary for early diagnosis and close monitoring of this disorder. Heart-type fatty acid binding protein (H-FABP), which mainly exists inside cardiomyocytes, has recently emerged as a potentially promising biomarker for myocardial injury. In this review we discuss the sensitivity and specificity of H-FABP in the assessment of myocardial injury and IRI, especially in the early stage, and its long-term prognostic value in comparison with other commonly used cardiac biomarkers, including myoglobin (Mb), cardiac troponin I (cTnI), creatine kinase MB (CK-MB), C-reactive protein (CRP), glycogen phosphorylase isoenzyme BB (GPBB), and high-sensitivity cardiac troponin T (hs-cTnT). The potential and value of combined application of H-FABP with other biomarkers are also discussed. Finally, the prospect of H-FABP is summarized; several technical issues are discussed to facilitate wider application of H-FABP in clin...Continue Reading

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Citations

Jun 22, 2018·Acta Pharmacologica Sinica·Lei XiNazareno Paolocci
Apr 6, 2019·Postgraduate Medical Journal·Yuqi ChenXiang Zhou
Oct 17, 2019·Metabolic Syndrome and Related Disorders·Rajesh Parsanathan, Sushil K Jain
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Aug 30, 2019·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Bo LiuChunsheng Li
May 21, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Alexander E Berezin, Alexander A Berezin
May 20, 2020·International Journal of Molecular Sciences·Peter JirakChristian Jung
Jun 11, 2019·Oxidative Medicine and Cellular Longevity·Liang GeZhengyuan Xia
Dec 1, 2018·European Journal of Applied Physiology·Jan-Frieder HarmsenMichael Behringer
Nov 3, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Albert TopfMichael Lichtenauer
Nov 23, 2021·Frontiers in Cardiovascular Medicine·Albert TopfRudin Pistulli

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Methods Mentioned

BETA
coronary artery bypass

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