Heart-type fatty acid binding protein (hFABP) in the diagnosis of myocardial damage in coronary artery bypass grafting
Heart-type fatty acid binding protein (hFABP) is an intracellular molecule engaged in the transport of fatty acids through myocardial cytoplasm and has been used as a rapid marker of myocardial infarction. However, its value in the evaluation of perioperative myocardial injury has not yet been assessed. 32 consecutive patients undergoing coronary artery bypass grafting were included in a prospective, randomized study using standardized operative procedures and myocardial protection. Three patients with perioperative myocardial infarction were added. Serial blood samples were taken preoperatively, before ischemia, 5 and 60 min after declamping, 1 and 6 h postoperatively and on postoperative days 1, 2 and 10 and were tested for hFABP, creatine kinase isoenzyme MB (CKMB) and troponin I (TnI). Hospital mortality was zero. The kinetics of the biochemical parameters revealed a typical pattern for each marker. In routine patients, hFABP levels peaked as early as 1 h after declamping, whereas CKMB and TnI peaked only 1 h after arrival in the intensive care unit. Patients with perioperative infarction displayed peak levels some hours later in all marker proteins. Peak serum levels of hFABP correlated significantly with peak levels of CK...Continue Reading
Development of a sandwich enzyme-linked immunosorbent assay for the determination of human heart type fatty acid-binding protein in plasma and urine by using two different monoclonal antibodies specific for human heart fatty acid-binding protein
Fatty-acid-binding protein as a plasma marker for the estimation of myocardial infarct size in humans
Demonstration of ischemia-reperfusion injury separate from postoperative infarction in coronary artery bypass graft patients
Cardiac troponin I plasma levels for diagnosis and quantitation of perioperative myocardial damage in patients undergoing coronary artery bypass surgery
A new principle for rapid immunoassay of proteins based on in situ precipitate-enhanced ellipsometry
Comparison of biochemical markers for the detection of minimal myocardial injury: superior sensitivity of cardiac troponin--T ELISA
Heart type fatty acid binding protein: structure, function and biosensing applications for early detection of myocardial infarction
Heart fatty acid binding protein in the rapid evaluation of myocardial damage following valve replacement surgery
Heart-type fatty acid binding protein is an independent predictor of death and ventricular dysfunction after coronary artery bypass graft surgery.
High peripheral levels of h-FABP are associated with poor prognosis in end-stage heart failure patients with mechanical circulatory support
Preoperative serum h-FABP concentration is associated with postoperative incidence of acute kidney injury in patients undergoing cardiac surgery
Perioperative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery
Remifentanil reduces the release of biochemical markers of myocardial damage after coronary artery bypass surgery: a randomized trial
Effects of autotransfusion of mediastinal shed blood on biochemical markers of myocardial damage in coronary surgery
Evaluation of heart fatty acid-binding protein as a rapid indicator for assessment of myocardial damage in pediatric cardiac surgery
Synergy of isoflurane preconditioning and propofol postconditioning reduces myocardial reperfusion injury in patients
Myocardial injury in coronary artery bypass grafting: on-pump versus off-pump comparison by measuring high-sensitivity C-reactive protein, cardiac troponin I, heart-type fatty acid-binding protein, creatine kinase-MB, and myoglobin release
Dexamethasone: benefit and prejudice for patients undergoing on-pump coronary artery bypass grafting: a study on myocardial, pulmonary, renal, intestinal, and hepatic injury
Liver fatty acid-binding protein is a diagnostic marker to detect liver injury due to chronic hepatitis C infection
Rapid analysis of fatty acid-binding proteins with immunosensors and immunotests for early monitoring of tissue injury
Liver fatty acid-binding protein: an early and sensitive plasma marker of hepatocellular damage and a reliable predictor of graft viability after liver transplantation from non-heart-beating donors
Heart fatty acid binding protein in the diagnosis of myocardial infarction: where do we stand today?
Diagnostic discrimination between graft-related and non-graft-related perioperative myocardial infarction with cardiac troponin I after coronary artery bypass surgery
ESC Joint Working Groups on Cardiovascular Surgery and the Cellular Biology of the Heart Position Paper: Perioperative myocardial injury and infarction in patients undergoing coronary artery bypass graft surgery.
Increases in serum concentration of human heart-type fatty acid-binding protein following elective coronary intervention
Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.