PMID: 11404143Jun 19, 2001Paper

Heart-type fatty acid binding protein (hFABP) in the diagnosis of myocardial damage in coronary artery bypass grafting

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
T PetzoldE Gams

Abstract

Heart-type fatty acid binding protein (hFABP) is an intracellular molecule engaged in the transport of fatty acids through myocardial cytoplasm and has been used as a rapid marker of myocardial infarction. However, its value in the evaluation of perioperative myocardial injury has not yet been assessed. 32 consecutive patients undergoing coronary artery bypass grafting were included in a prospective, randomized study using standardized operative procedures and myocardial protection. Three patients with perioperative myocardial infarction were added. Serial blood samples were taken preoperatively, before ischemia, 5 and 60 min after declamping, 1 and 6 h postoperatively and on postoperative days 1, 2 and 10 and were tested for hFABP, creatine kinase isoenzyme MB (CKMB) and troponin I (TnI). Hospital mortality was zero. The kinetics of the biochemical parameters revealed a typical pattern for each marker. In routine patients, hFABP levels peaked as early as 1 h after declamping, whereas CKMB and TnI peaked only 1 h after arrival in the intensive care unit. Patients with perioperative infarction displayed peak levels some hours later in all marker proteins. Peak serum levels of hFABP correlated significantly with peak levels of CK...Continue Reading

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Citations

Jun 7, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hong LiuHua Jing
Apr 2, 2015·Kidney International·Jennifer A SchaubUNKNOWN TRIBE-AKI Consortium
Jan 9, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Gordon T C WongMichael G Irwin
Jan 6, 2005·The Journal of Thoracic and Cardiovascular Surgery·Tomomi HasegawaYutaka Okita
Jan 18, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maurice M A L PelsersJan F C Glatz
Jun 3, 2004·The Journal of Thoracic and Cardiovascular Surgery·Tomomi HasegawaMasahiro Yamaguchi
Jul 20, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hitoshi NaraokaHideaki Tojo
Nov 19, 2002·Journal of Physiology and Biochemistry·A MartiJ A Martínez
Jun 26, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Eftihia SbarouniVassilis Voudris
Apr 21, 2004·British Journal of Anaesthesia·M KempJ Hooper

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