[Heart valve and myocardial tissue engineering].

Herz
Serghei CebotariA Haverich

Abstract

Cardiac function, including the heart muscle and valves, can be severely altered by congenital and acquired heart diseases. Several graft materials are currently used to replace diseased cardiac tissue and valvular segments. Implantable grafts are either non-vital or can trigger an immune response which leads to graft calcification and degeneration. None of the existing grafts have the ability to remodel and grow in tandem with the physiological growth of a child and therefore require re-operation. Novel approaches such as tissue engineering have emerged as possible alternatives for cardiac reconstruction. The main concept of tissue engineering includes the use of biological and artificial scaffolds that form the shape of the organ structures for subsequent tissue replacement, which will provide absolute biocompatibility, no thrombogenicity, no teratogenicity, long-term durability and growth.Heart valve tissue engineering represents an important field especially in pediatric patients with valve pathologies. In order to create an autologous valve equivalent myofibroblasts and/or endothelial cells are seeded on specially designed scaffolds. Here we describe the different types of cell sources and different types of matrices curre...Continue Reading

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Citations

Aug 10, 2015·Biotechnology Advances·Soumen Jana, Amir Lerman
Feb 26, 2015·Journal of Tissue Engineering and Regenerative Medicine·Soumen JanaAmir Lerman
Jun 6, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Rebecca JeyarajAaron Tan
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May 20, 2017·Biomedizinische Technik. Biomedical Engineering·Tobias SchillingThomas Hassel
Dec 13, 2019·Frontiers in Cardiovascular Medicine·Paolo MadedduGaia Spinetti
Feb 19, 2020·Journal of the American Heart Association·Valeria Vincenza AlvinoPaolo Madeddu

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