Heart valve calcification and calcium x phosphorus product in hemodialysis patients: analysis of optimum values for its prevention

Kidney International. Supplement
Margarita RufinoVictor Lorenzo

Abstract

Prevalence of valve calcification (VC) in end-stage renal disease (ESRD) patients is high and information regarding modifiable predictors is scarce. Our aim was to determine the prevalence of VC in our maintenance hemodialysis (HD) population, and the optimal Ca x P value that most accurately predicted the presence of VC after controlling for comorbidities. This was a cross-sectional observational study of a cohort of 52 stable patients on maintenance HD for more than 12 months. Mean 12 months serum biochemical data (calcium, phosphorus, PTH, lipids) and M-mode 2D echocardiogram were used to evaluate the presence or absence of mitral and aortic VC and ventricular geometry. Twenty patients (38.4%) presented with VC. Patients with VC were more commonly diabetic and showed higher levels of serum phosphorus, Ca x P product, total and LDL cholesterol, and poor ventricular geometry, as compared to patients without VC. Moreover, they required higher doses of both CaCO3 and Al(OH)3. Logistic regression analysis showed that VC was independently influenced by age, Ca x P, and diabetes. ROC curves illustrated that a Ca x P>43 mg2/dL2 was the optimal value in terms of sensitivity and specificity for predicting the presence of VC in our pat...Continue Reading

References

Jan 1, 1994·Nephron·A E Raine
Mar 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J BraunF C Luft
Apr 8, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G A BlockF K Port
Aug 27, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S RibeiroF Ribeiro
Jul 15, 1999·The New England Journal of Medicine·C M OttoD S Siscovick
Dec 22, 1999·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M YoshidaN Ohsawa
Apr 7, 2000·Journal of the American Society of Nephrology : JASN·Gérard M LondonAlain P Guerin
May 18, 2000·The New England Journal of Medicine·W G GoodmanI B Salusky
Jun 10, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G A Block, F K Port
Jun 22, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A P GuérinF Metivier
Sep 20, 2001·Journal of the American Society of Nephrology : JASN·Santhi K GaneshFriedrich K Port

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Citations

Sep 30, 2005·Seminars in Dialysis·Naveed N MasaniJohn K Maesaka
Apr 23, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Diana Y Y ChiuPhilip A Kalra
Aug 7, 2004·Kidney International. Supplement·Wajeh Y Qunibi
Oct 6, 2006·Expert Opinion on Pharmacotherapy·Akhtar AshfaqPravin C Singhal
Aug 25, 2015·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Carmen Sánchez-PeralesAntonio Liébana
Jan 7, 2015·Nature Reviews. Nephrology·Diana Y Y ChiuPhilip A Kalra
Sep 25, 2012·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Narin OsmanPeter J Little
Jan 15, 2009·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Ryota IkeeShuzo Kobayashi
Sep 30, 2009·Nature Reviews. Nephrology·M Khaled Shamseddin, Patrick S Parfrey
May 15, 2009·The International Journal of Artificial Organs·Dejan PetrovićBiljana Stojimirović
Aug 4, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hiromichi TaniwakiYoshiki Nishizawa

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