Heart valve sclerosis predicts all-cause and cardiovascular mortality

Atherosclerosis
Henry VölzkeMarcus Dörr

Abstract

Aortic valve sclerosis (AVS) and mitral annulus calcification (MAC) might predict future adverse events. We undertook the present study to investigate the association of AVS and MAC with all-cause and cardiovascular mortality. We further studied whether a combined presence of AVS and MAC is more strongly associated with mortality than the single items and sought to disclose possible gender differences in the investigated associations. We used data from 2081 participants aged > or =45 years (1063 women) of the Study of Health in Pomerania (SHIP). AVS and MAC were determined echocardiographically, and a heart valve sclerosis score was calculated by summing up the AVS and MAC variables. The median duration of mortality follow-up was 8.6 years (17,162 person-years). There were 528 subjects (25.4%) with isolated AVS, 35 with isolated MAC (1.7%) and 89 with both AVS and MAC (4.3%). A total number of 228 deaths (11.0%) occurred during follow-up, including 133 (21.6%) with AVS and 95 subjects (6.5%) without AVS (incidence rate ratio 3.49, 95% CI 2.77; 4.40, p<0.001). Likewise, mortality rates were higher for subjects with MAC than subjects without MAC (incidence rate ratio 3.79, 95% CI 2.82; 5.02, p<0.001). Multivariable analyses revea...Continue Reading

References

Jul 15, 1999·The New England Journal of Medicine·C M OttoD S Siscovick
May 11, 2002·Science·Jim Oeppen, James W Vaupel
Mar 26, 2003·Circulation·Caroline S FoxUNKNOWN Framingham Heart Study
Jan 5, 2005·Clinical Cardiology·Yogendra Prasad, Narendra C Bhalodkar
Dec 13, 2005·American Heart Journal·Henry VölzkeThomas Kocher
Mar 2, 2006·Journal of Hypertension·Christa MeisingerJan Lüdemann
Jun 24, 2006·Journal of Hypertension·Henry VölzkeThomas Kocher

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Citations

Dec 18, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Jill Wylie-SearsJoyce Bischoff
Dec 7, 2013·International Heart Journal·Soe Hee AnnHo-Joong Youn
Jun 28, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Paolo RaggiPaul Muntner
Nov 9, 2010·European Radiology·Martijn J A GondrieUNKNOWN PROVIDI Study Group
Jul 31, 2013·Expert Review of Cardiovascular Therapy·George LazarosNalini Rajamannan
Jan 27, 2016·Digestive Diseases and Sciences·Alessandro MantovaniGiovanni Targher
Nov 16, 2013·International Journal of Cardiology·Danitza PradelliPompilio Faggiano
Apr 21, 2012·Pharmacology & Therapeutics·D T NgoJ D Horowitz
Jul 23, 2015·Aging Clinical and Experimental Research·Cuihong XieYongsheng Li
Feb 8, 2011·The American Journal of Medicine·S Michael GharacholouPatricia A Pellikka
May 7, 2013·The American Journal of Cardiology·David LeibowitzDan Gilon
Oct 10, 2013·BioMed Research International·Gregg S PressmanVincent M Figueredo
May 13, 2014·Journal of the American College of Cardiology·Sean CoffeyMichael J A Williams
Feb 20, 2016·Clinical Hypertension·Jae-Hwan Lee, Jae-Hyeong Park
May 13, 2015·The International Journal of Cardiovascular Imaging·Martin J WilleminkPim A de Jong
May 11, 2015·Metabolism: Clinical and Experimental·Alessandro MantovaniGiovanni Targher
Oct 16, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Marvin Louis Roy LuGregg S Pressman
Jun 18, 2017·Journal of the American College of Cardiology·Mehdi AfsharUNKNOWN CHARGE Extracoronary Calcium Working Group
May 21, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Marcello Ricardo Paulista MarkusWolfgang Lieb
Oct 29, 2015·Journal of the American Heart Association·Ana M PorrasKristyn S Masters
Aug 8, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Kristof HirschbergHugo A Katus
Dec 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ana M PorrasKristyn S Masters
Sep 20, 2020·Echocardiography·Tom Kai Ming WangMilind Y Desai
Dec 28, 2012·Polish journal of radiology·Jarosław WasilewskiLech Poloński

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