DOI: 10.1101/487744Dec 7, 2018Paper

HeartBioPortal: an internet-of-omics for human cardiovascular disease data

BioRxiv : the Preprint Server for Biology
Bohdan KhomtchoukThemistocles Assimes


Cardiovascular disease (CVD) is the leading cause of death worldwide, causing over 17M deaths per year, which outpaces global cancer mortality rates. Despite these sobering statistics, the state-of-the-art in computational infrastructure to study datasets associated with CVD has lagged far behind public resources widely available in the oncology field, where improved data science and visualization methods have led to the development of large-scale cancer genomics resources like MSKCC's cBioPortal or NCI's Genomic Data Commons (GDC) Portal. Developing a similar user-friendly computational platform could significantly lower the barriers between complex CVD data and researchers who want rapid, intuitive, and high-quality visual access to molecular profiles and clinical attributes from existing CVD projects. Here we present HeartBioPortal: a publicly available web application that provides intuitive visualization, analysis, and downloads of large-scale CVD data currently focused on gene expression, genetic association, and ancestry information. By democratizing access to anonymized CVD data, HeartBioPortal's aim is to integrate relevant omics and clinical information across the biological dataverse to support CVD clinicians and res...Continue Reading

Related Concepts

Cardiovascular Diseases
Cessation of Life
Gene Expression
Circulating Neoplastic Cells
Research Personnel
Carcinoma, Large Cell
Oncology Field

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