HeartLogic Multisensor Algorithm Identifies Patients During Periods of Significantly Increased Risk of Heart Failure Events: Results From the MultiSENSE Study

Circulation. Heart Failure
Roy S GardnerJohn P Boehmer

Abstract

Care of heart failure (HF) patients results in a high burden on healthcare resources, and estimating prognosis is becoming increasingly important to triage resources wisely. Natriuretic peptides are recommended prognosticators in chronic HF. Our objective was to evaluate whether a multisensor HF index and alert algorithm (HeartLogic) replaces or augments current HF risk stratification. MultiSENSE (Multisensor Chronic Evaluation in Ambulatory Heart Failure Patients) enrolled 900 patients with cardiac resynchronization therapy defibrillators enabled for collection of heart sounds, respiration, thoracic impedance, heart rate, and activity data. The HeartLogic algorithm automatically calculated a daily HF index and identified periods IN or OUT of an active alert state relative to a configurable threshold. Patients experienced 192 independently adjudicated HF events (average rate, 0.20/patient-year [pt-yr]) during 1 year of follow-up. HF event rates while IN alert was 10-fold higher than OUT of alert (0.80 versus 0.08 events/pt-yr). Combined with NT-proBNP (N-terminal pro-B-type natriuretic peptide) at enrollment (relative to 1000 pg/mL threshold, event rate was 0.42 [HIGH] versus 0.07 [LOW] events/pt-yr), substratification found th...Continue Reading

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Citations

Jul 14, 2018·Circulation. Heart Failure·Maria Rosa Costanzo
Apr 19, 2020·Clinical Cardiology·Luca SantiniAlessandro Capucci
Nov 21, 2019·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·J F Veenis, J J Brugts
Jun 21, 2020·Current Cardiology Reports·Omaima AliJohn P Boehmer
Oct 17, 2020·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Pamela K MasonJagmeet P Singh
Jan 26, 2021·Current Treatment Options in Cardiovascular Medicine·Medhat FarwatiW H Wilson Tang
Mar 27, 2021·European Journal of Heart Failure·Neal A Chatterjee, Wayne C Levy
Apr 23, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Spencer Z RoseroValentina Kutyifa
Jul 1, 2021·Circulation. Heart Failure·Leonardo CalòUNKNOWN Full list of participant centers and investigators
Aug 6, 2021·Journal of Cardiac Failure·Jeffrey L ChilcoteJason L Guichard
Aug 16, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Antonio D'OnofrioLuigi Padeletti
Dec 5, 2020·JACC. Heart Failure·Ersilia M DeFilippisMariell Jessup
Jan 24, 2022·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Matteo BertiniLeonardo Calò

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