Heat: A Highly Efficient Skin Enhancer for Transdermal Drug Delivery

Frontiers in Bioengineering and Biotechnology
Sabine Szunerits, Rabah Boukherroub

Abstract

Advances in materials science and bionanotechnology have allowed the refinements of current drug delivery systems, expected to facilitate the development of personalized medicine. While dermatological topical pharmaceutical formulations such as foams, creams, lotions, gels, etc., have been proposed for decades, these systems target mainly skin-based diseases. To treat systemic medical conditions as well as localized problems such as joint or muscle concerns, transdermal delivery systems (TDDSs), which use the skin as the main route of drug delivery, are very appealing. Over the years, these systems have shown to offer important advantages over oral as well as intravenous drug delivery routes. Besides being non-invasive and painless, TDDSs are able to deliver drugs with a short-half-life time more easily and are well adapted to eliminate frequent administrations to maintain constant drug delivery. The possibility of self-administration of a predetermined drug dose at defined time intervals makes it also the most convenient personalized point-of-care approach. The transdermal market still remains limited to a narrow range of drugs. While small and lipophilic drugs have been successfully delivered using TDDSs, this approach fails ...Continue Reading

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Citations

Feb 8, 2019·Current Pharmaceutical Design·Nagarani ThotakuraPenke Vijaya Babu
Jul 5, 2019·Nanoscale·Li ChengnanSabine Szunerits
May 26, 2018·Nanotechnology·Ivana BoriševAleksandar Djordjevic
Jul 23, 2020·Drug Delivery and Translational Research·Rabinarayan Parhi, Aishwarya Mandru
Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Luis Abelardo Villarruel MendozaPaolo Nicolas Catalano
Oct 6, 2020·Frontiers in Pharmacology·Aaron J SnoswellTarl W Prow
Jan 10, 2021·Journal of Clinical Medicine·Vahid AlimardaniSamad Ahadian
Jan 27, 2021·Therapeutic Delivery·Faris Soloman Almadi, Saad I Mallah
Feb 4, 2021·Biomicrofluidics·Magalí Mercuri, David Fernandez Rivas
Mar 8, 2021·International Journal of Pharmaceutics·Álvaro Cárcamo-MartínezRyan F Donnelly
Jul 30, 2021·Biomaterials Research·Woo Yeup JeongKi Su Kim
Feb 19, 2019·ACS Applied Materials & Interfaces·Yi XiangWenguo Cui
Sep 4, 2021·Beilstein Journal of Nanotechnology·Sepand Tehrani FatehAmin Shiralizadeh Dezfuli
Aug 21, 2021·Current Pharmaceutical Design·Sana KalaveAmbikanandan Misra
Jan 19, 2022·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Bilal DemirSabine Szunerits

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Methods Mentioned

BETA
hormone replacement therapy
chemical treatment
fluorescence microscopy
surface plasmon resonance

Software Mentioned

Tjet

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