Heat-induced programmed cell death in Leishmania infantum is reverted by Bcl-X(L) expression

Apoptosis : an International Journal on Programmed Cell Death
Juan Fernando AlzateAntonio Jiménez-Ruiz

Abstract

An increasing number of reports indicate that single-celled organisms are able to die following what seems to be an ordered program of cell death with strong similarities to apoptosis from higher eukaryotes. DNA degradation and several other apoptotic-like processes have also been described in the parasitic protozoa Leishmania. However, the existence of an apoptotic death in this parasite is still a matter of controversy. Our results indicate that most of the processes of macromolecular degradation and organelle dysfunction observed in mammalian cells during apoptosis can also be reproduced in promastigotes of the genus Leishmania when incubated at temperatures above 38 degrees C. These processes can be partially reversed by the expression of the anti-apoptotic mammalian gene Bcl-X(L), which suggests that this family of apoptosis-regulating proteins was present very early in the evolution of eukaryotic cells.

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Citations

Oct 6, 2010·Parasitology Research·David MorenoCarmen Sanmartín
Feb 6, 2013·The Journal of Experimental Medicine·Bidyottam MittraNorma W Andrews
Jun 15, 2007·Plant & Cell Physiology·Anna ZuppiniBarbara Baldan
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