PMID: 9172013Dec 1, 1996Paper

Heat-killed Bacillus subtilis inhibits T-cell proliferative response to mitogens and recall antigens

International Journal of Immunopharmacology
J GaoA Turano

Abstract

Heat-killed vegetative forms of Bacillus subtilis were found to impair considerably the capacity of human T-lymphocytes to secrete interleukin-2 (IL-2) and to proliferate (in terms of [3H]thymidine incorporation) after phytohaemagglutinin (PHA) stimulation. B. subtilis was also found to interfere with T-cell proliferation induced by concanavalin A (Con A) and the recall antigen tetanus toxoid (TT). The suppressive activity was dependent on bacterial concentration, and was not ascribed to mitogen, medium-nutrient absorption or cell killing. Moreover, B. subtilis did not interfere with mitogen-induced IL-2 receptor expression on the T-cell surface. On the other hand, B. subtilis did not interfere with T-cell proliferation induced by phorbol myristate acetate (PMA) and ionomycin stimulation. All data obtained suggest the binding of B. subtilis subcomponents to- or very close to-the T-cell receptor (TCR). Identification and purification of the basic structure(s) or component(s) of B. subtilis with TCR antagonist activity in vitro will help to exploit different aspects of T-cell activity and development, and possibly, will provide a means of specific control or modification of the immune response.

References

Jul 1, 1992·Immunology Today·A Arnaiz-VillenaJ R Regueiro
Jan 1, 1988·Immunology Today·A Cerami, B Beutler
Dec 1, 1983·The Journal of Experimental Medicine·D A Cantrell, K A Smith

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