Heat shock cognate protein 70 is involved in rotavirus cell entry

Journal of Virology
Carlos A GuerreroCarlos F Arias

Abstract

In this work, we have identified the heat shock cognate protein (hsc70) as a receptor candidate for rotaviruses. hsc70 was shown to be present on the surface of MA104 cells, and antibodies to this protein blocked rotavirus infectivity, while not affecting the infectivity of reovirus and poliovirus. Preincubation of the hsc70 protein with the viruses also inhibited their infectivity. Triple-layered particles (mature virions), but not double-layered particles, bound hsc70 in a solid-phase assay, and this interaction was blocked by monoclonal antibodies to the virus surface proteins VP4 and VP7. Rotaviruses were shown to interact with hsc70 at a postattachment step, since antibodies to hsc70 and the protein itself did not inhibit the virus attachment to cells. We propose that the functional rotavirus receptor is a complex of several cell surface molecules that include, among others, hsc70.

References

Jun 19, 1992·International Journal of Cancer. Journal International Du Cancer·M FerrariniC Rugarli
Mar 1, 1988·Journal of Pediatric Gastroenterology and Nutrition·D J Keljo, A K Smith
Dec 1, 1995·Journal of Virology·T P CripeR L Garcea
Apr 10, 1995·International Journal of Cancer. Journal International Du Cancer·G MulthoffR D Issels
Mar 1, 1994·Trends in Microbiology·S Jindal, M Malkovsky
Sep 1, 1996·Cell Stress & Chaperones·G Multhoff, L E Hightower
Oct 10, 1998·Journal of Virology·M D RolsmaM S Kuhlenschmidt
Apr 10, 1999·Journal of Virology·C L ParksS A Udem
May 1, 1999·Biological Chemistry·R PrangeH Löffler-Mary
May 7, 1999·Infectious Diseases in Obstetrics and Gynecology·B G Brenner, M A Wainberg
Nov 2, 1999·Virology·E MéndezC F Arias
Jan 7, 2000·Journal of Virology·S ZárateS López
Feb 8, 2000·The Journal of Biological Chemistry·A C SaphireL Gerace
Jul 19, 2000·The Journal of Biological Chemistry·N Arispe, A De Maio
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R J BinderP K Srivastava
Sep 23, 2000·Journal of Virology·C A GuerreroC F Arias
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·C A GuerreroC F Arias
Jul 11, 2001·Novartis Foundation Symposium·C F AriasS López

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Citations

May 13, 2010·Archives of Virology·Allen XiaoHonglin Luo
Sep 18, 2002·Archives of Medical Research·Carlos F AriasSusana López
Mar 26, 2010·Journal of Medicinal Chemistry·Christopher G EvansJason E Gestwicki
Apr 15, 2011·The Journal of Biological Chemistry·Dipanjan DuttaMamta Chawla-Sarkar
May 14, 2009·Viral Immunology·Luz-Stella RodríguezJuana Angel
Nov 24, 2012·Journal of Virology·Marco A Díaz-SalinasCarlos F Arias
Apr 5, 2002·Journal of Virology·Mariela A CuadrasHarry B Greenberg
Jun 14, 2003·Journal of Virology·Selene ZárateSusana López
Jul 16, 2004·Journal of Virology·Santanu BoseAmiya K Banerjee
Jun 10, 2003·Microbiology and Molecular Biology Reviews : MMBR·Nathalie Chazal, Denis Gerlier
Apr 26, 2007·Annual Review of Cell and Developmental Biology·Billy Tsai
Sep 10, 2009·Reproductive Biology and Endocrinology : RB&E·Kenta WatanabeMasahisa Watarai
Nov 20, 2012·Virology Journal·Zhongqi BianZhaoxin Zheng
Mar 1, 2012·Virology Journal·Vinod R M T BalasubramaniamSharifah S Hassan
Aug 2, 2006·Biological & Pharmaceutical Bulletin·Takashi Suzuki, Yasuo Suzuki
May 16, 2014·BioMed Research International·Nayeli Alva-MurilloAlejandra Ochoa-Zarzosa
May 23, 2014·Journal of Biosciences·Mandar S Paingankar, Vidya A Arankalle
Jan 25, 2013·Archives of Virology·Tania Olivia Vega-AlmeidaJuan Santiago Salas-Benito
Nov 20, 2013·Journal of Structural and Functional Genomics·Xing Yu, Helen Blanchard
Jan 1, 2014·Uirusu·Satoshi Komoto, Koki Taniguchi
Sep 24, 2008·Virus Research·Salvador Chavez-SalinasRosa M Del Angel
Jun 14, 2005·The British Journal of Dermatology·J StebbingM Bower
May 13, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Romain ParentLaura Beretta
Feb 3, 2006·EMBO Reports·Santiago F ElenaRafael Sanjuán
May 29, 2004·Trends in Microbiology·Susana López, Carlos F Arias

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