Heat shock factor 1 in protein homeostasis and oncogenic signal integration

Cancer Research
Trisha HomeRekha Rao

Abstract

Heat shock factor 1 (HSF1) is a stress-inducible transcription factor and has been described as a multi-faceted modulator of tumorigenesis. Heat shock, accumulation of misfolded proteins, or malignant transformation promotes the activation and nuclear translocation of HSF1, where it binds to the promoters of heat shock proteins and an array of nonheat shock-regulated proteins to upregulate their transcription. These stress-responsive and tumor-promoting genes in turn alter the ability of tumor cells to respond to a variety of stresses and enable them to thrive in less than favorable growth conditions. Although a direct role for HSF1 in promoting mRNA transcription of tumor-promoting genes has been suggested, it appears that this property is context- and cell-type dependent. Furthermore, recent studies have demonstrated a direct involvement of mTOR signaling in regulating HSF1-mediated transcription, thus establishing a direct link between protein translation and HSF1 activity. Interestingly, there is a growing understanding of the signaling pathways that are modulated by HSF1 in a variety of tumor types and the co-option of these survival pathways by HSF1 to promote tumorigenesis. This review will focus on the role of HSF1 in p...Continue Reading

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Citations

May 18, 2016·Scientific Reports·Xiao-Yan PanShu-Wen Liu
Aug 19, 2016·Frontiers in Oncology·Pratikkumar Harsukhbhai VekariaRekha Rao
Dec 27, 2017·Journal of Gastroenterology and Hepatology·Yoichiro KawashitaMitsuo Shimada
Nov 18, 2017·BMC Biology·Sara Sannino, Jeffrey L Brodsky
Jul 2, 2020·Cellular and Molecular Life Sciences : CMLS·Silvia SantopoloM Gabriella Santoro
Sep 29, 2018·Journal of Experimental & Clinical Cancer Research : CR·Matteo CaforioValentina Folgiero
May 11, 2017·International Journal of Molecular Medicine·Yi-Fei ChenLi Wang
Jun 16, 2019·Journal of Experimental & Clinical Cancer Research : CR·Mara CironeGabriella D'Orazi

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