Heat shock increases antigenic peptide generation but decreases antigen presentation

European Journal of Immunology
E PépinM G Colomb

Abstract

The heat shock response is a universal and highly conserved cellular response to stress. We describe here the effect of elevated temperature on the capacity of B cells to present antigen. Heat shock markedly affects the ability of these cells to process and present tetanus toxin to class II-restricted T cell clones. Inhibition of antigen presentation is due neither to a modification of antigen capture nor to a variation of major histocompatibility complex (MHC) class II molecule synthesis and cell surface expression. Stressed and nonstressed B cells are able to present peptides loaded at the cell surface with the same efficiency. Nevertheless, heat shock leads to an increase of antigen peptide generation in subcellular compartments; an enhancement of cathepsin B activity is also observed. These data suggest that such a stress induces a failure in the intracellular peptide loading onto MHC class II molecules.

References

Jan 2, 1992·Nature·M J Gething, J Sambrook
Nov 1, 1991·European Journal of Immunology·G KuperbergB M Chain
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M Clerget, B S Polla
May 1, 1990·Immunology Today·D N KhansariR E Faith
Jan 1, 1989·Cold Spring Harbor Symposia on Quantitative Biology·P Panina-BordignonA Lanzavecchia
Jan 1, 1988·Annual Review of Genetics·S Lindquist, E A Craig
Apr 11, 1985·Nature·A Lanzavecchia
Jun 1, 1982·European Journal of Immunology·A LanzavecchiaF Celada
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A Dautry-VarsatH F Lodish
Aug 1, 1994·Immunology Today·L Hoffman-Goetz, B K Pedersen
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·M A MarićJ S Blum
Jan 1, 1993·Annual Review of Cell Biology·C Georgopoulos, W J Welch
Feb 1, 1996·Current Opinion in Immunology·R Busch, E D Mellins
Dec 1, 1995·Seminars in Immunology·S Ceman, A J Sant

❮ Previous
Next ❯

Citations

Sep 10, 2005·Cancer Immunology, Immunotherapy : CII·Valeria Milani, Elfriede Noessner
Nov 25, 2003·Cell Stress & Chaperones·Olivier Preynat-SeauveChristian Villiers
Apr 15, 2010·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Munitta MuthanaA Graham Pockley
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcin P MyckoKrzysztof W Selmaj
Apr 7, 2016·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Gabriele MulthoffStephanie E Combs

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.