PMID: 11906938Mar 22, 2002Paper

Heat shock-induced apoptosis in preimplantation bovine embryos is a developmentally regulated phenomenon

Biology of Reproduction
F F Paula-Lopes, Peter J Hansen

Abstract

Apoptosis is a form of cell death that can function to eliminate cells damaged by environmental stress. One stress that can compromise embryonic development is elevated temperature (i.e., heat shock). For the current studies, we hypothesized that heat shock induces apoptosis in bovine embryos in a developmentally regulated manner. Studies were performed to 1) determine whether heat shock can induce apoptosis in preimplantation embryos, 2) test whether heat-induced apoptosis is developmentally regulated, 3) evaluate whether heat shock-induced changes in caspase activity parallel patterns of apoptosis, and 4) ascertain whether exposure to a mild heat shock can protect embryos from heat-induced apoptosis. As determined by TUNEL reaction, exposure of bovine embryos > or =16 cells on Day 5 after insemination to 41 or 42 degrees C for 9 h increased the percentage of cells undergoing apoptosis. In addition, there was a duration-dependent increase in the proportion of blastomeres that were apoptotic when embryos were exposed to temperatures of 40 or 41 degrees C, which are more characteristic of temperatures experienced by heat-stressed cows. Heat shock also increased caspase activity in Day 5 embryos. However, heat shock did not induc...Continue Reading

References

Jun 1, 1992·Journal of Cellular Physiology·D D Mosser, L H Martin
Jun 1, 1995·Biology of Reproduction·C F AréchigaP J Hansen
Jun 1, 1996·The Journal of Cell Biology·M WeilM C Raff
Feb 1, 1997·Molecular Reproduction and Development·J L Edwards, P J Hansen
Feb 7, 1997·Cell·M D JacobsonM C Raff
Mar 7, 1997·Biochemical Pharmacology·L A PeñaR Kolesnick
Sep 1, 1997·Molecular Reproduction and Development·J L EdwardsP J Hansen
Sep 1, 1997·Molecular and Cellular Biology·D D MosserB Massie
Jan 1, 1997·British Medical Bulletin·A Haimovitz-FriedmanZ Fuks
May 9, 1998·Neurosurgery·T FuseK Yamada
Nov 26, 1998·Biology of Reproduction·F F Paula-LopesP J Hansen
Jan 8, 1999·Cell Stress & Chaperones·A Samali, S Orrenius
Jun 16, 1999·Molecular Reproduction and Development·J C JuX Yang
Oct 16, 1999·Reviews of Reproduction·K Hardy
Jan 25, 2000·Journal of Reproduction and Fertility·A T ByrneH J Leese
Jun 7, 2000·Zygote : the Biology of Gametes and Early Embryos·C MatweeW A King
Aug 10, 2000·Nature Cell Biology·A SalehE S Alnemri
Sep 13, 2000·Molecular and Cellular Biology·D D MosserB Massie
Oct 26, 2000·Nature·P MeierG Evan
Jan 3, 2001·Biology of Reproduction·L J Van Winkle
Jan 9, 2001·Trends in Cell Biology·H M Beere, D R Green
Apr 1, 1986·Theriogenology·J J ParrishN L First

❮ Previous
Next ❯

Citations

May 2, 2002·Molecular Reproduction and Development·Y M Al-Katanani, P J Hansen
May 10, 2005·Theriogenology·Alexandre Tavares Duarte de OliveiraJosé Luiz Rodrigues
Jun 27, 2002·Biochemical and Biophysical Research Communications·F F Paula-Lopes, P J Hansen
May 12, 2011·Reproduction, Fertility, and Development·Nathan T BainDean H Betts
May 30, 2003·Biology of Reproduction·Jakob O GjørretPoul Maddox-Hyttel
Feb 13, 2004·Biology of Reproduction·Rocío M RiveraPeter J Hansen
Aug 20, 2004·Biology of Reproduction·Z Roth, P J Hansen
Feb 16, 2008·The Journal of Reproduction and Development·Frank Dean JousanPeter James Hansen
Oct 17, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·S AsafZ Roth
Jul 3, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Rocío Melissa RiveraPeter J Hansen
Jul 20, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Bárbara LoureiroPeter James Hansen
Jul 13, 2012·Zygote : the Biology of Gametes and Early Embryos·Mateus José SudanoFernanda da Cruz Landim-Alvarenga
Sep 13, 2013·Reproduction, Fertility, and Development·Mateus J SudanoFernanda D C Landim-Alvarenga
Sep 11, 2012·Reproduction, Fertility, and Development·Grazieli M MachadoMargot A N Dode
Oct 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Peter J Hansen
Oct 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Cheryl J AshworthMorag G Hunter
Oct 3, 2002·Prenatal Diagnosis
Mar 23, 2011·Tissue Engineering. Part a·Frank TavassolMartin Rücker
Aug 12, 2009·Biochemical and Biophysical Research Communications·Silvia F CarambulaPeter J Hansen
Mar 10, 2009·Biochemical and Biophysical Research Communications·Yong-Guang GongRen-Shan Ge
Jan 28, 2009·Theriogenology·Katherine E M Hendricks, Peter J Hansen
Oct 28, 2008·Molecular Reproduction and Development·S Clay IsomEdmund B Rucker
Jan 13, 2011·American Journal of Reproductive Immunology : AJRI·Bárbara LoureiroPeter J Hansen
Dec 6, 2008·Reproduction in Domestic Animals = Zuchthygiene·G AntunesF Moreira da Silva
Jan 11, 2014·Diabetes/metabolism Research and Reviews·Aline BuenoDébora Cristina Damasceno
Jun 16, 2005·Theriogenology·Dusan FabianPoul Maddox-Hyttel
Oct 7, 2015·Environmental Science & Technology·Patrick B HamiltonCharles R Tyler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis