Heat shock protein 70 is required for optimal liver regeneration after partial hepatectomy in mice

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Joshua H WolfMatthew H Levine

Abstract

Liver regeneration is a complex process that restores functional tissue after resection or injury, and it is accompanied by transient adenosine triphosphate depletion and metabolic stress in hepatic parenchymal cells. Heat shock protein 70 (Hsp70) functions as a chaperone during periods of cellular stress and induces the expression of several inflammatory cytokines identified as key players during early liver regeneration. We, therefore, hypothesized that Hsp70 is required for the initiation of regeneration. Investigations were carried out in a 70% partial hepatectomy mouse model with mice lacking inducible Hsp70 (Hsp70(-/-)). Liver regeneration was assessed postoperatively with the liver weight/body weight (LW/BW) ratio, and sera and tissues were collected for analysis. In addition, the expression of Hsp-related genes was assessed in a cohort of 23 human living donor liver transplantation donors. In mice, the absence of Hsp70 was associated with a reduced postoperative LW/BW ratio, Ki-67 staining, and tumor necrosis factor α (TNF-α) expression in comparison with wild-type mice. TNF-α expression was also reduced in livers from Hsp70(-/-) mice after induction with lipopolysaccharide (1 mg/kg). Clinically, the transcription of mu...Continue Reading

References

Aug 2, 1993·FEBS Letters·V L Gabai, A E Kabakov
Apr 4, 1997·Science·G K Michalopoulos, M C DeFrances
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K OhashiH Kolb
Jun 27, 2002·European Journal of Biochemistry·Ferruccio GuerrieriMargherita Greco
May 15, 2003·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Arin K Greene, Mark Puder
Jan 1, 2004·Molecular and Cellular Biology·Clayton R HuntTej K Pandita
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nelson FaustoKimberly J Riehle
Aug 13, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sara CrummJan B Hoek
Jul 24, 2010·Nature Reviews. Molecular Cell Biology·Harm H Kampinga, Elizabeth A Craig
Aug 30, 2011·Cell Stress & Chaperones·Jordan Thomas Silver, Earl G Noble
Jan 11, 2013·The Journal of Biological Chemistry·Jun-Seok BaeKyungpyo Park
Mar 16, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael A ZimmermanRobert M Merion

❮ Previous
Next ❯

Citations

May 8, 2014·Gastroenterology·Raghavendra RaoGeorge Miller
Apr 11, 2015·Journal of Cellular Biochemistry·Biljana MiovaNadezda Apostolova
Dec 25, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Tao MaTingbo Liang
Oct 1, 2016·Oncotarget·Na Li, Jinlian Hua
Mar 24, 2017·Cell and Tissue Research·Yousra Ben KhadraMaria Daniela Candia Carnevali
Aug 17, 2018·BioMed Research International·Yue HaoXianhong Gu
Oct 23, 2018·Scandinavian Journal of Gastroenterology·Jae Min LeeChang Duck Kim
Oct 22, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Zhi-Yong HeHu Wei-Yan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
S B IbirogbaD Kahn
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Timucin TanerJulie K Heimbach
Transplant International : Official Journal of the European Society for Organ Transplantation
Hideki IshidaHiroshi Toma
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Yoichiro UchidaJerzy W Kupiec-Weglinski
© 2021 Meta ULC. All rights reserved