PMID: 9421355Jan 8, 1998Paper

Heat shock protein 72/73 in relation to cytoplasmic p53 expression and prognosis in colorectal adenocarcinomas

International Journal of Cancer. Journal International Du Cancer
X F SunB Nordenskjöld

Abstract

Heat shock proteins (hsp) are molecular chaperones that are increased by various environmental and patho-physiological stimuli. Hsp can bind to mutant/wild-type p53 in tumors and, consequently, could not only regulate p53 accumulation or localization but also modulate its biological effects on cells. However, there is little information available on the significance of hsp expression in colorectal cancer. The aim of our study was to investigate the relationship of hsp to p53 expression, clinico-pathological factors and prognosis in a series of 256 patients with colorectal adenocarcinomas, using immuno-histochemistry. Seventy-five cases exhibited hsp expression in the cytoplasm, with 11 presenting both cytoplasmic and nuclear staining. Hsp expression was related positively to cytoplasmic p53 expression but not to nuclear p53 expression. In the subgroup of rectal tumors, hsp over-expression appeared to predict unfavorable survival, though its prognostic value diminished using multivariate analysis. There were no significant relationships of hsp with patient sex or age, tumor site, Duke's stage, growth pattern or differentiation.

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Citations

Dec 28, 2007·Journal of Virology·Dweepanita DasMichael J Imperiale
Jun 19, 2007·Antioxidants & Redox Signaling·Eui Jung MoonMark W Dewhirst
Feb 13, 2016·Cell Stress & Chaperones·Jürgen Radons
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Feb 22, 2002·The Journal of Surgical Research·Klaus GüntherMarc A Reymond
Sep 2, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·X F SunB Nordenskjöld
Oct 6, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ewa MaluseckaZdzislaw Krawczyk
Dec 24, 2013·Cancers·Kata JuhaszZsolt Balogi
Mar 17, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Burçin TunaHülya Ellidokuz
Jun 15, 2007·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·T HamamotoM Watanabe
Aug 9, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Firouzeh HeidariManouchehr Nakhjavani
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·A JanssonX F Sun
Nov 21, 1998·Cancer Detection and Prevention·K NanbuT Mori
Mar 25, 2017·Oncology Reports·Xin-Xin LiuJian-Ying Zhang

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