Heat-Shock Protein 90-Targeted Nano Anticancer Therapy

Journal of Pharmaceutical Sciences
Ankit K RochaniD Sakthi Kumar

Abstract

Suboptimal chemotherapy of anticancer drugs may be attributed to a variety of cellular mechanisms, which synergize to dodge the drug responses. Nearly 2 decades of heat-shock protein 90 (Hsp90)-targeted drug discovery has shown that the mono-therapy with Hsp90 inhibitors seems to be relatively ineffective compared with combination treatment due to several cellular dodging mechanisms. In this article, we have tried to analyze and review the Hsp90 and mammalian target of rapamycin (m-TOR)-mediated drug resistance mechanisms. By using this information we have discussed about the rationale behind use of drug combinations that includes both or any one of these inhibitors for cancer therapy. Currently, biodegradable nano vector (NV)-loaded novel drug delivery systems have shown to resolve the problems of poor bioavailability. NVs of drugs such as paclitaxel, doxorubicin, daunorubicin, and others have been successfully introduced for medicinal use. Hence, looking at the success of NVs, in this article we have also discussed the progress made in the delivery of biodegradable NV-loaded Hsp90 and m-TOR-targeted inhibitors in multiple drug combinations. We have also discussed the possible ways by which the market success of biodegradable ...Continue Reading

References

Nov 11, 1976·Biochimica Et Biophysica Acta·R L Juliano, V Ling
Jan 1, 1975·Biochemical Society Transactions·C M Colley, B E Ryman
Sep 16, 1992·Biochemical and Biophysical Research Communications·M MiyazakiM Kuwano
Apr 1, 1991·Journal of Microencapsulation·C Dong, J A Rogers
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K UedaI Pastan
Sep 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·Y E RahmanJ F Thomson
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·N TeradaE W Gelfand
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·L WhitesellL M Neckers
Oct 7, 1998·International Journal of Cancer. Journal International Du Cancer·L M Vargas-RoigD R Ciocca
Jun 11, 1999·Genes & Development·A C GingrasN Sonenberg
Jan 19, 2000·Trends in Biochemical Sciences·R Dutta, M Inouye
Feb 19, 2000·Current Opinion in Structural Biology·L H Pearl, C Prodromou
Aug 29, 2000·Immunopharmacology·P Moseley
Apr 3, 2002·Trends in Molecular Medicine·Len Neckers
Apr 1, 1971·FEBS Letters·G GregoriadisB E. Ryman
Jun 7, 2002·Nature·Christine QueitschSusan Lindquist
Dec 25, 2002·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·A J DavisI F Tannock
Feb 1, 2003·Current Drug Targets·Nguyen-Hai Nam, Keykavous Parang
Feb 14, 2003·The Journal of Biological Chemistry·Gowrishankar BanumathyUtpal Tatu
Feb 15, 2003·Journal of Pharmaceutical Sciences·Nikhil O Dhoot, Margaret A Wheatley
Jul 25, 2003·International Journal of Pharmaceutics·Delphine MallardéRomano Deghenghi
Dec 8, 1962·Nature·A D BANGHAMJ A LUCY
Mar 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y MatsumuraK Takahashi
Feb 16, 2005·Annual Review of Physiology·Dietmar Kültz
Jun 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Udai BanerjiIan Judson
Sep 22, 2005·Nature Reviews. Cancer·Luke Whitesell, Susan L Lindquist
Dec 31, 2005·Molecular and Cellular Biology·Thierry TchénioFrançois Dautry
Jan 6, 2006·Journal of Medicinal Chemistry·Huazhong HeGabriela Chiosis
Feb 18, 2006·Trends in Biochemical Sciences·Stuart K CalderwoodDaniel R Ciocca
Mar 23, 2006·The Journal of Biological Chemistry·Ami CitriYosef Yarden
Jun 29, 2006·British Journal of Haematology·Denis R Miller
Nov 15, 2006·Current Cancer Drug Targets·Mehmet Alper ArslanHuveyda Basaga
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lanie K FrancisIrene M Ghobrial

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Cancer Metabolism: Therapeutic Targets

Targeting the mechanisms by which cancer cells acquire energy for metabolic needs is a therapeutic target. Discover the latest research on cancer metabolism and therapeutic targets.

Related Papers

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Emily B BordersPatrick J Medina
Current Opinion in Cell Biology
Saskia BrachmannCarlos García-Echeverría
Expert Opinion on Pharmacotherapy
Ivy Altomare, Herbert Hurwitz
© 2022 Meta ULC. All rights reserved