PMID: 8938273Dec 1, 1995Paper

Heat shock protein-based cancer vaccines and related thoughts on immunogenicity of human tumors

Seminars in Cancer Biology
N E Blachere, P K Srivastava

Abstract

Heat shock proteins (HSPs) are associated in vivo with the entire repertoire of peptides (antigenic and otherwise) generated within that cell. Immunization with such non-covalent HSP-peptide complexes is unusually efficient in eliciting cellular immune responses against the antigenic peptides associated with the HSPs. This broad and general principle is the basis for a new generation of vaccines against cancers and infectious diseases and circumvents the need for identification of the T-cell epitopes for any given cancer or infectious agent.

References

May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A B DeLeoL J Old
Oct 1, 1991·European Journal of Immunology·A R LussowG Del Giudice
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M SchulzH Hengartner
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D L BarndO J Finn
Mar 1, 1988·Immunology Today·P K Srivastava, L J Old
Sep 1, 1988·The New England Journal of Medicine·P C Nowell
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P K SrivastavaL J Old
Mar 15, 1984·International Journal of Cancer. Journal International Du Cancer·P K Srivastava, M R Das
Oct 9, 1995·International Journal of Cancer. Journal International Du Cancer·A M Feldweg, P K Srivastava
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·H UdonoP K Srivastava
Jul 1, 1994·The Journal of Experimental Medicine·A N Houghton
Mar 1, 1994·The Journal of Experimental Medicine·A B BakkerC G Figdor
Nov 1, 1993·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·N E BlachereP K Srivastava
Oct 1, 1993·The Journal of Experimental Medicine·H Udono, P K Srivastava
Jul 1, 1995·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Y TosaK Kato

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Citations

May 12, 2005·Cancer Immunology, Immunotherapy : CII·Yi ZengEmmanuel Katsanis
Jul 21, 2004·Clinics in Dermatology·Ian KomenakaHoward L Kaufman
Mar 22, 2002·The Lancet Oncology·J D Wolchok, P O Livingston
Apr 20, 2004·Journal of Translational Medicine·Roopa Srinivasan, Jedd D Wolchok
Feb 18, 2010·Immunotherapy·Nona JanikashviliEmmanuel Katsanis
Nov 1, 2013·Pakistan Journal of Biological Sciences : PJBS·Kuldeep DhamaSanjay Kapoor
Jan 27, 2009·Advanced Drug Delivery Reviews·David M Lubaroff, Dev Karan
Oct 6, 1998·Hematology/oncology Clinics of North America·J D WolchokA N Houghton
Mar 16, 2001·Expert Opinion on Pharmacotherapy·R S Chamberlain, H Kaufman
Jul 19, 2005·Expert Opinion on Investigational Drugs·Ahmad A Tarhini, Sanjiv S Agarwala
Feb 20, 2002·Biologicals : Journal of the International Association of Biological Standardization·P M van Endert
Apr 28, 1999·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M PandeyM K Nair
Jan 9, 2007·Critical Reviews in Oncology/hematology·Bernd KasperAhmad Awada
Aug 22, 2002·The Journal of Biological Chemistry·Shawn VogenYair Argon
Nov 27, 2002·Cancer Investigation·Miguel-Angel Perales, Jedd D Wolchok
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R Lo-ManC Leclerc
Mar 14, 2021·Molecular Diagnosis & Therapy·Sadia Islam Kana, Karim Essani
Nov 6, 2007·International Journal of Pharmaceutics·Makiya NishikawaYoshinobu Takakura

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