PMID: 7519530Aug 1, 1994Paper

Heat shock protein peptides reactive in patients with Behçet's disease are uveitogenic in Lewis rats

Clinical and Experimental Immunology
Miles R StanfordThomas Lehner

Abstract

Mycobacterial and homologous human heat shock protein T cell peptide epitopes specific for T lymphocytes in Behçet's disease were investigated for their pathogenicity in Lewis rats. The potential pathogenicity of eight peptides and two controls was assessed by administering the peptides in enriched Freund's adjuvant into the footpads of male Lewis rats. Anterior uveitis which is a major manifestation of Behçet's disease was induced with two out of the four mycobacterial and all four homologous human peptides. The most effective peptides inducing iridocyclitis in 64-75% of rats were peptides with amino acids 336-351 and 136-150, derived from the sequence of the human 60-kD heat shock protein. A few of the rats also showed evidence of focal loss of photoreceptors. These results suggest that selected peptides within heat shock protein 60 kD which function as T cell epitopes in Behçet's disease are capable of inducing uveitis in rats. This supports the view that the peptide T cell determinants may be involved in the pathogenesis of Behçet's disease.

References

Jan 12, 1991·Lancet·D B Jones, G Duff
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D EliasI R Cohen
Jan 2, 1992·Nature·M J Gething, J Sambrook
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D EliasI R Cohen
Nov 9, 1989·Nature·G Gammon, E Sercarz
Dec 1, 1989·The Journal of Experimental Medicine·A VanbuskirkS K Pierce
Dec 1, 1989·Arthritis and Rheumatism·J B Winfield
Aug 1, 1989·The Journal of Experimental Medicine·M F van den BroekW B van den Berg
Jan 1, 1988·Annual Review of Genetics·S Lindquist, E A Craig
Jun 1, 1988·Immunology Today·Y Shoenfeld, D A Isenberg
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D YoungR A Young
Sep 11, 1987·Cell·M B Oldstone
Dec 1, 1985·Infection and Immunity·J E TholeJ D van Embden
Sep 1, 1985·The British Journal of Dermatology·F KanekoY Miura
Jan 1, 1984·The Journal of Clinical Investigation·J HoloshitzI R Cohen

❮ Previous
Next ❯

Citations

Jan 1, 1997·International Journal of Clinical & Laboratory Research·R RizziR Dammacco
Nov 5, 1999·Brain : a Journal of Neurology·D KiddP Rudge
Aug 27, 2019·Frontiers in Immunology·Martin BuschArnd Heiligenhaus
Jul 31, 2003·Neuropathology and Applied Neurobiology·E H Hughes, A D Dick
Oct 21, 1999·The New England Journal of Medicine·T SakaneG Inaba
Jul 6, 2014·Ocular Immunology and Inflammation·Sebastiaan J VastertDebra A Goldstein
Dec 29, 2006·Annals of the New York Academy of Sciences·John G Routsias, Athanasios G Tzioufas
Jul 15, 1999·Clinical and Experimental Immunology·H DireskeneliT Akoglu
Feb 17, 1999·Experimental Eye Research·E UchioT Lehner
Jun 30, 2000·La Revue de médecine interne·B GranelP J Weiller
Aug 7, 2013·Molecular Immunology·Carlos Alvarez-Navarro, José A López de Castro
Jan 9, 1999·Clinical Microbiology Reviews·U Zügel, S H Kaufmann
Jun 22, 2005·Survey of Ophthalmology·Cem Evereklioglu
May 1, 1997·Baillière's Clinical Rheumatology·V HamuryudanH Yazici
Oct 21, 2010·Autoimmunity Reviews·Alessandra Goncalves CommodaroLuiz Vicente Rizzo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.