Heat-shock proteins can promote as well as regulate autoimmunity.

Autoimmunity Reviews
Rajesh Rajaiah, Kamal D Moudgil

Abstract

Heat-shock proteins (Hsps) are among the most highly conserved and immunogenic proteins shared by microbial agents and mammals. Under physiological conditions, the ubiquitously distributed Hsps maintain the integrity and function of other cellular proteins when cells are exposed to stressful stimuli. However, owing to their conserved nature and stress inducibility, Hsps may become targets of immune response. The T cells and/or antibodies induced by a microbial Hsp may crossreact with the corresponding mammalian Hsp (molecular mimicry) and trigger an autoimmune response, which if unchecked can lead to immune pathology and clinical manifestations. Furthermore, enhanced expression of Hsp under stress can unveil previously hidden antigenic determinants that can initiate and perpetuate autoimmune reactivity. Also, the innate immune mechanisms activated by an Hsp can reinforce and even direct the type of adaptive immune response to that protein. Hsps have been implicated in the induction and propagation of autoimmunity in several diseases, including rheumatoid arthritis, atherosclerosis and type 1 diabetes. However, Hsps possess immunoregulatory attributes as well and therefore, are being exploited for immunomodulation of various imm...Continue Reading

References

Aug 9, 2003·Springer Seminars in Immunopathology·Berent J PrakkenWillem van Eden
Nov 2, 2005·Human Gene Therapy·Rubens R Santos-JuniorCélio L Silva
Jul 3, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Xu Yin JiYoun-Soo Hahn
Jul 24, 2007·Autoimmunity Reviews·Jean-Eric AlardChristophe Jamin
Aug 5, 2008·Trends in Immunology·Kamal D Moudgil, Malarvizhi Durai
Sep 2, 2008·Cell Stress & Chaperones·Verônica CoelhoKamal D Moudgil

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Citations

Feb 18, 2011·Archives of Dermatological Research·J A O'DalyN R Indriago
Dec 31, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Daming ZuoXiang-Yang Wang
Apr 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Cecilia GrundtmanGeorg Wick
Jul 18, 2009·Genetic Vaccines and Therapy·Larissa Lumi Watanabe IshikawaAlexandrina Sartori
Nov 26, 2009·PloS One·Eliana B MarengoOsvaldo Augusto Sant'Anna
Oct 1, 2011·PloS One·Eliana B MarengoOsvaldo Augusto Sant'Anna
Jan 30, 2014·PloS One·Katherine TaylorDeborah A Kimbrell
Jun 7, 2012·Molecular Medicine·María José MansillaCarmen Espejo
Mar 29, 2014·Immunity & Ageing : I & a·Estevam José BaldonOsvaldo Augusto Sant'anna
Feb 5, 2013·Future Microbiology·Davide CossuLeonardo A Sechi
Jun 3, 2014·Journal of Neuroinflammation·Carmen NoelkerAndreas Hartmann
Jan 15, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A ArsovicD Baskic
Jun 26, 2009·Clinical Reviews in Allergy & Immunology·Jozélio Freire de CarvalhoYehuda Shoenfeld
Jun 14, 2013·Autoimmune Diseases·Kamal D MoudgilYehuda Shoenfeld
Jan 15, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Shivaprasad H VenkateshaKamal D Moudgil
Mar 27, 2013·La Revue de médecine interne·K-H LyE Vidal
Jun 21, 2011·Autoimmunity Reviews·R RamondaA Doria
Feb 16, 2011·Autoimmunity Reviews·Yu-Tsan LinBor-Luen Chiang
Mar 15, 2016·Frontiers in Immunology·Daming ZuoXiang-Yang Wang
Jul 20, 2010·Journal of Autoimmunity·Francesca BernuzziGilberto Filaci
Aug 19, 2010·Autoimmunity Reviews·Carlo Selmi
May 12, 2010·Autoimmunity Reviews·Kim-Heang LyLuc Mouthon
May 12, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Karen L WoodAndrea I Doseff
Oct 6, 2009·Journal of Autoimmunity·Malarvizhi DuraiKamal D Moudgil
Nov 26, 2009·Autoimmunity Reviews·Anna Dubaniewicz
Sep 22, 2009·Neuroscience Letters·Chi-Un PaeAlessandro Serretti
Apr 11, 2013·Autoimmune Diseases·E W BrenuS M Marshall-Gradisnik
Jul 30, 2010·Mycoses·Reinhard B RaggamWalter Buzina
Mar 22, 2012·Veterinary Ophthalmology·Johanna K ZippliesCornelia A Deeg
Oct 20, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Catharina ErikssonKarl-Gösta Sundqvist
Mar 19, 2016·Cell Death and Differentiation·D R GreenJ Martinez
Jul 12, 2013·Journal of Parasitology Research·José A O'DalyMaría B Rodríguez

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