Heat shock proteins, cell survival and drug resistance: the mitochondrial chaperone TRAP1, a potential novel target for ovarian cancer therapy

Gynecologic Oncology
Matteo LandriscinaFranca Esposito

Abstract

Protein homeostasis is a highly complex network of molecular interactions governing the health and life span of the organism. Molecular chaperones, mainly heat shock proteins (HSP) and other stress-inducible proteins abundantly expressed in multiple compartments of the cell, are major modulators of protein homeostasis. TRAP1 is a mitochondrial HSP involved in protection against oxidant-induced DNA damage and apoptosis. It was recently described as a component of a mitochondrial pathway selectively up-regulated in tumor cells which antagonizes the proapoptotic activity of cyclophilin D, a mitochondrial permeability transition pore regulator, and is responsible for the maintenance of mitochondrial integrity, thus favoring cell survival. Interestingly, novel TRAP1 antagonists cause sudden collapse of mitochondrial function and selective tumor cell death, suggesting that this pathway may represent a novel molecular target to improve anticancer therapy. Preliminary data suggest that TRAP1 may be a valuable biomarker in ovarian cancers: in fact, TRAP1 levels are significantly higher in cisplatin-resistant ovarian tumors and ovarian carcinoma cell lines. While major advances have been made in understanding the genetics and molecular b...Continue Reading

References

Mar 11, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M MarkmanJ L Lewis
Oct 7, 1998·International Journal of Cancer. Journal International Du Cancer·L M Vargas-RoigD R Ciocca
Feb 1, 2000·The Journal of Biological Chemistry·S J FeltsD O Toft
Jul 27, 2001·The Journal of Cell Biology·J C YoungF U Hartl
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Mar 23, 2002·Progress in Molecular and Subcellular Biology·André-Patrick ArrigoChantal Diaz-Latoud
Jun 25, 2003·Cell Stress & Chaperones·Daniel R CioccaO Graciela Scharovsky
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert F OzolsUNKNOWN Gynecologic Oncology Group
Sep 4, 2003·Journal of the National Cancer Institute·Andreas du BoisUNKNOWN Arbeitsgemeinschaft Gynäkologische Onkologie Ovarian Cancer Study Group
Oct 8, 2003·Current Cancer Drug Targets·Udai BanerjiPaul Workman
Oct 12, 2004·Drug Discovery Today·Gabriela ChiosisDavid Solit
Nov 13, 2004·Cell Cycle·Mads Gyrd-HansenMarja Jäättelä
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
May 17, 2005·Cancer Cell·Janet PlesciaDario C Altieri
Jul 26, 2005·Cell Stress & Chaperones·Daniel R Ciocca, Stuart K Calderwood
Aug 3, 2005·Cancer Research·Kenneth MacleodSimon P Langdon
Sep 22, 2005·Nature Reviews. Cancer·Luke Whitesell, Susan L Lindquist
Mar 23, 2006·Free Radical Research·Nicola Montesano GesualdiFranca Esposito
Aug 3, 2006·Journal of the National Cancer Institute·Boglarka GyurkoczaDario C Altieri
Sep 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jacobus PfistererUNKNOWN EORTC GCG
Nov 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jens R SydorJeffrey K Tong
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David B SolitHoward I Scher
Sep 14, 2007·Stress : the International Journal on the Biology of Stress·N Montesano GesualdiF Esposito
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Sharmila ShankarRakesh K Srivastava
Dec 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shanu ModiClifford A Hudis

❮ Previous
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Citations

May 11, 2012·Future Medicinal Chemistry·Z NahlehZ Nahle
Apr 6, 2012·Cell Stress & Chaperones·Lonneke HeldensNicolette H Lubsen
Nov 22, 2011·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Marissa Nichole RylanderKenneth R Diller
Jul 9, 2011·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mauro B AlmeidaMaria Elena Crespo-López
Sep 1, 2015·Critical Reviews in Oncology/hematology·M B StopeA Mustea
Sep 10, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Wen TanYitao Wang
Sep 27, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qingjie LvYafei Qi
May 25, 2011·Biochimica Et Biophysica Acta·Ashraf A KhalilChristopher Smith
Mar 17, 2012·Cell Cycle·Rahul S SamantPaul Workman
Oct 26, 2010·Biochimica Et Biophysica Acta·Liam PorttMichael T Greenwood
Sep 6, 2014·Journal of Molecular Neuroscience : MN·Shuai LiYun-Hui Liu
Jul 5, 2012·Biochemical Pharmacology·Phuong Minh NguyenWilliam K Chan
Mar 29, 2016·PloS One·Mashitoh Abd RahmanNajihah Mohd Hashim
Jul 19, 2017·Expert Review of Molecular Diagnostics·Celeste Caruso BavisottoClaudia Campanella
Sep 16, 2017·International Journal of Molecular Sciences·Suman Chatterjee, Timothy F Burns
Sep 28, 2017·Cell Stress & Chaperones·Mayra L Sottile, Silvina B Nadin
Oct 12, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jingjing ZhangHongxia Li
Jan 27, 2017·International Journal of Pharmaceutical Investigation·Naveen KanthamneniYin-Chao Tseng
Jan 4, 2020·Oncology Letters·Warne Pedro De AndradeAgnaldo Lopes Da Silva Filho
Dec 11, 2014·World Journal of Gastroenterology : WJG·Ru ChenTeresa A Brentnall
May 11, 2017·International Journal of Molecular Medicine·Yi-Fei ChenLi Wang
Jul 22, 2015·Archives of Pharmacal Research·Young Ho Seo
Oct 22, 2019·Future Medicinal Chemistry·Tiantian ZhangChanghu Xue
Feb 26, 2014·Molecular Cancer Research : MCR·Jackeline AgorretaFrancesco Pezzella
Jun 4, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P K LakshmiRajesh Singh Pawar

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