Heat shock proteins: conditional mediators of inflammation in tumor immunity.

Frontiers in Immunology
Stuart K CalderwoodJianlin Gong

Abstract

Heat shock protein (HSP)-based anticancer vaccines have undergone successful preclinical testing and are now entering clinical trial. Questions still remain, however regarding the immunological properties of HSPs. It is now accepted that many of the HSPs participate in tumor immunity, at least in part by chaperoning tumor antigenic peptides, introducing them into antigen presenting cells such as dendritic cells (DC) that display the antigens on MHC class I molecules on the cell surface and stimulate cytotoxic lymphocytes (CTL). However, in order for activated CD8+ T cells to function as effective CTL and kill tumor cells, additional signals must be induced to obtain a sturdy CTL response. These include the expression of co-stimulatory molecules on the DC surface and inflammatory events that can induce immunogenic cytokine cascades. That such events occur is indicated by the ability of Hsp70 vaccines to induce antitumor immunity and overcome tolerance to tumor antigens such as mucin1. Secondary activation of CTL can be induced by inflammatory signaling through Toll-like receptors and/or by interaction of antigen-activated T helper cells with the APC. We will discuss the role of the inflammatory properties of HSPs in tumor immuni...Continue Reading

Citations

Jan 30, 2014·PloS One·Katherine TaylorDeborah A Kimbrell
Feb 28, 2013·International Journal of Molecular Sciences·Jirina TyleckovaHana Kovarova
Oct 12, 2012·Autoimmune Diseases·Stuart K CalderwoodAyesha Murshid
Dec 7, 2013·Neuro-oncology·Maxim A ShevtsovBoris A Margulis
Aug 26, 2014·European Urology·Alexandra Masson-LecomteNúria Malats
Aug 22, 2015·Veterinary Immunology and Immunopathology·Satoru OkadaKazumi Sasai
Jul 13, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Irina V GuzhovaBoris A Margulis
May 21, 2016·Frontiers in Immunology·Stuart K CalderwoodAyesha Murshid
Jun 14, 2016·Human Vaccines & Immunotherapeutics·Irina V Guzhova, Boris A Margulis
Dec 24, 2013·Cancers·Kata JuhaszZsolt Balogi
Apr 22, 2018·British Journal of Pharmacology·Bernardo Rodriguez-IturbeRichard J Johnson
Dec 1, 2017·Journal of Immunotherapy·Marlene F LaursenEmil Kofod-Olsen
Dec 12, 2013·Expert Review of Clinical Immunology·Alka Bhatia, Yashwant Kumar
Jul 9, 2020·Cancers·Estela Noguera-OrtegaEsther Julián
Aug 21, 2021·Biochemical Society Transactions·Stuart K CalderwoodThomas L Prince
Jun 15, 2013·Proteome Science·Enbing TianQingtao Wang

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