Heat shock proteins in obesity: links to cardiovascular disease

Hormone Molecular Biology and Clinical Investigation
Christiane Habich, Henrike Sell

Abstract

Adipose tissue expansion is associated with adipocyte dysfunction and increased inflammatory processes. In the obese state, adipose tissue is characterized by an impaired intracellular stress defense system and dysbalanced heat shock response. Several members of the heat shock protein (HSP) family have been identified as novel adipokines released upon cellular stress, which might be a molecular link from adipose tissue inflammation to the cardiovascular system. Therefore, this review aims at summarizing and discussing our recent knowledge on HSPs in relation to obesity and their potential links to cardiovascular disease. Of particular importance/interest are two members of the HSP family, HSP60 and heme oxygenase 1 (HO-1), which have been well described as adipokines, and studied in the context of obesity and cardiovascular disease. HSP60 is regarded as a novel molecular link between adipose tissue inflammation and obesity-associated insulin resistance. The role of HO-1 induction in the obese state is well-documented, but a causal relationship between increased HO-1 levels and obesity-associated metabolic diseases is still controversial. Both HSP60 and HO-1 are also forthcoming targets for the treatment of cardiovascular diseas...Continue Reading

References

Oct 24, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·E NisoliM O Carruba
Mar 23, 2004·Annual Review of Immunology·Georg WickQingbo Xu
Mar 9, 2005·Molecular & Cellular Proteomics : MCP·James P DeLanyJeffrey M Gimble
May 17, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M Ghayour-MobarhanG A A Ferns
Feb 20, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sanjiv Gupta, A A Knowlton
Oct 9, 2007·Methods : a Companion to Methods in Enzymology·H Elyse IrelandJohn H H Williams
Dec 12, 2007·Handbook of Experimental Pharmacology·Alexzander Asea
Jan 15, 2008·Autoimmunity Reviews·Julia Hurst, Philipp von Landenberg
Jan 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jason ChungMark A Febbraio
Feb 13, 2008·Journal of Cellular and Molecular Medicine·D LanneauC Garrido
Jul 16, 2008·FEBS Letters·Elke GüldenChristiane Habich
Feb 12, 2009·American Journal of Physiology. Endocrinology and Metabolism·Joseph Fomusi NdisangAshok Jadhav
Aug 19, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S Shakeri-ManeschT M Stulnig
Mar 5, 2010·Metabolism: Clinical and Experimental·Darren C HenstridgeBarbora de Courten
Aug 19, 2010·American Journal of Physiology. Endocrinology and Metabolism·Hironori AdachiEiichi Araki
Oct 6, 2010·Molecular BioSystems·Kedra CyrusKyung-Bo Kim
Oct 23, 2010·Molecular Cell·Klaus RichterJohannes Buchner
Jan 5, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kinga Musiał, Danuta Zwolińska
Jan 15, 2011·Journal of Applied Physiology·Brittany K GorresPaige C Geiger
May 25, 2011·Haematologica·Djordje AtanackovicNicolaus Kröger
May 31, 2011·Frontiers in Bioscience (Landmark Edition)·William Durante
Jul 16, 2011·European Neurology·Fredrik RomiNils Erik Gilhus
Jan 4, 2012·Proteomics. Clinical Applications·Stefan LehrHenrike Sell
Mar 15, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Angela P H BurgessAttallah Kappas
Feb 5, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Z A MalikA A Knowlton
May 28, 2013·The Journal of Endocrinology·Karen OlivaMartha Lappas
Jan 18, 2014·Circulation Research·Anders Waldenström, Gunnar Ronquist
May 21, 2014·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·A IslamP A Deuster

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