Heat stress prevents impairment of bile acid transport in endotoxemic rats by a posttranscriptional mechanism

Gastroenterology
Ulrich BolderKarl-Walter Jauch

Abstract

Endotoxemia leads to reduction of bile acid transporters in the hepatocyte membrane and impaired bile acid transport. Because heat stress ameliorates other sequelae of endotoxemia, studies were performed to determine whether heat stress would correct deficient bile acid transport caused by endotoxin. Body temperature of rats was elevated to 42 degrees C for 10 minutes. Lipopolysaccharide was injected after different time intervals, and maximal transport for cholyltaurine was measured in perfused rat livers. Sodium-dependent and -independent uptake was studied in isolated hepatocytes. Protein expression, messenger RNA levels, and tissue distribution of the bile acid transporters sodium taurocholate cotransporting protein (ntcp) and bile salt export pump (bsep) were also analyzed. In the perfused liver, cholyltaurine transport was reduced by 59% by endotoxin, but transport was not reduced when heat stress was applied 2 hours before injection of lipopolysaccharide. The protective effect coincided with maximal expression of heat shock proteins 70 and 25. Sodium-dependent and -independent transport was preserved by heat stress. Expression of bile acid transporters in plasma membrane fractions was reduced after injection of lipopolys...Continue Reading

References

Jun 1, 1992·The Journal of Cell Biology·R P BeckmannW J Welch
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B HagenbuchP J Meier
Mar 1, 1991·Experimental Cell Research·B A MargulisL V Smagina
May 1, 1994·Trends in Biochemical Sciences·U Jakob, J Buchner
Oct 1, 1994·Gastroenterology·H RoelofsenR P Oude Elferink
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·E JacqueminP J Meier
Jan 1, 1996·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·D Wissing, M Jäättelä
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
May 1, 1996·Seminars in Liver Disease·B Hagenbuch, P J Meier
Oct 23, 1997·Critical Care Medicine·E K ChuA S Slutsky
May 23, 1998·The Journal of Biological Chemistry·T GerloffP J Meier
Oct 22, 1998·The New England Journal of Medicine·M TraunerJ L Boyer
Jan 26, 1999·Annals of the New York Academy of Sciences·M J KlugerD Soszynski
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R M MinterL L Moldawer

❮ Previous
Next ❯

Citations

Dec 6, 2008·World Journal of Gastroenterology : WJG·Marcelo G RomaAldo D Mottino
Dec 7, 2017·Current Medicinal Chemistry·Marcelo G RomaEnrique J Sánchez Pozzi
Feb 11, 2005·Current Opinion in Gastroenterology·Michael Trauner, James L Boyer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.