PMID: 6105437Aug 9, 1980Paper

Heat stroke: report on 18 cases

Lancet
M Khogali, J S Weiner

Abstract

Eighteen hyperpyrexial patients with a mean rectal temperature of 42.3 degrees (range 41.2-43.1 degrees C) were rapidly cooled in a unit producing evaporative cooling from a warm skin. Sixteen patients recovered, and two, who were diabetic, died. The time taken for the core temperature to drop to 38 degrees C varied from 26 min to 5 h. The success of a treatment which maintained vasodilatation by warming the skin accords with the hypothesis that peripheral vasoconstriction combined with a high metabolic heat output is a major factor in the pathogenesis of heat stroke.

References

Feb 1, 1972·The Journal of Clinical Investigation·J P KnochelR J Hamburger
Mar 8, 1980·Lancet·J S Weiner, M Khogali

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Citations

Jan 1, 1991·Intensive Care Medicine·J F TimsitH Corsin
Jan 1, 1983·General Pharmacology·A O ElkhawadM Khogali
May 20, 1998·Journal of the Neurological Sciences·B Yaqub, S Al Deeb
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May 28, 2004·Emergency Medicine Clinics of North America·Nannette M Lugo-AmadorPeter Moyer

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