Heating of indoor dust causes reduction in its ability to stimulate release of IL-8 and TNFalpha in vitro compared to non-heated dust

Indoor Air
Mette MathiesenTore Syversen

Abstract

Dust is a major contaminant of the indoor air environment and may affect human health. Indoor dust accumulates on surfaces including heaters and light fixtures, and will be heated when these devices are used. Heat treatment of the dust may change its biologic properties and in this study we simulated the heat treatment with a dust-heating model (50-250 degrees C). The residual and the non-heated dust from seven samples were tested in cultures of fresh peripheral blood mononuclear cells and in A549 cell culture using the release of TNFalpha and IL-8, respectively, as effect indicators. The endotoxin-content and the particle size distribution of the residual and the non-heated dust suspensions were determined for some of the samples. We found that the residual dust had less ability to induce the release of TNFalpha and IL-8. The cytokine decline pattern was similar for all the dust tested and could partly be explained by the reduction in endotoxin content or possibly by inhibitory decomposition products. No correlation was found between the measured particle size distribution and the decreased cytokine levels. The results in this study suggest that the residual dust promotes reduced cytokine response and thereby a possibly lower ...Continue Reading

References

Jan 15, 1976·International Journal of Cancer. Journal International Du Cancer·M LieberG Todaro
Jun 1, 1976·Scandinavian Journal of Immunology·A Bøyum
Apr 1, 1984·Environmental Health Perspectives·D H Bowden
Apr 1, 1984·Environmental Health Perspectives·D E Gardner
Dec 1, 1993·Environmental Health Perspectives·J M Samet, F E Speizer
Jun 1, 1996·Occupational and Environmental Medicine·D M Brown, K Donaldson
Jul 20, 1999·Journal of Immunological Methods·L A HansenH Würtz
Jun 1, 2000·Journal of Toxicology and Environmental Health. Part a·R B HetlandP E Schwarze
Aug 31, 2000·Toxicology and Applied Pharmacology·A ImrichL Kobzik
Mar 1, 2002·Environment International·Ellen Katrine PedersenMette Mathiesen
Sep 25, 2002·Indoor Air·L MølhaveJ Attermann
Jun 21, 2003·International Journal of Clinical Pharmacology and Therapeutics·M Müller
Aug 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·U Griwatz, N H Seemayer

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Citations

May 27, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Lei XiaoXiaoqin Luo
Jun 9, 2009·Nihon eiseigaku zasshi. Japanese journal of hygiene·Yasuo MorimotoTetsuo Takanami

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