PMID: 2115570Aug 1, 1990Paper

Heavy-chain class switch does not terminate somatic mutation

The Journal of Experimental Medicine
H ShanM Weigert

Abstract

We studied the H-chain class switch rearrangement in four groups of clonally related B cell hybridomas, to test the hypothesis that class switch terminates somatic mutation in a B cell. Using switch region-specific probes in Southern blot analysis individual mu-gamma switch rearrangement events can be distinguished. We show that clonally related IgG-producing hybridomas that differ by mutations often share a common switch rearrangement. This indicates that class switch in these cells did not terminate somatic mutation.

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Citations

Jun 19, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N S GreenM D Scharff
Apr 1, 1994·Molecular Immunology·R A InselE Marin
Feb 1, 1991·Current Opinion in Immunology
Nov 15, 2002·Molecular Immunology·Nayun KimUrsula Storb
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Jan 1, 1992·Current Biology : CB·J L RabinowitzM D Scharff
Feb 13, 2003·British Journal of Haematology·Satoshi ShiokawaJunji Nishimura
Oct 1, 1992·European Journal of Immunology·J H van EsT Logtenberg

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