Heavy metal and trace element concentrations in blood and follicular fluid affect ART outcome

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Harun Egemen TolunayMurat Sönmezer

Abstract

To assess the effects of heavy metal and trace element concentrations in blood and follicular fluid on assisted reproductive technology cycle outcome. A prospective study was conducted between January 2012 and July 2012 in a university hospital infertility clinic. One hundred and one patients with unexplained infertility who underwent intracytoplasmic sperm injection using GnRH-antagonist protocol were recruited. Concentrations of four toxic metals (Cd, Pb, Hg, As) and three trace elements (Cu, Zn, Fe) were measured both in blood and follicular fluid specimens. Patients were evaluated in two groups; the study group consisted of patients with ongoing pregnancy (n=20) and the reference group consisted of patients experienced assisted reproductive technology failure, miscarriage or biochemical pregnancy (n=81). Demographics and cycle parameters were comparable between the groups except for median number of day 3 Grade A embryos. Statistically significant negative correlations were found between blood Pb levels and number of MII oocytes, implantation, clinical pregnancy and ongoing pregnancy rates. Results of the log binomial regression revealed 2.2% lower risk for ongoing pregnancy for each 1μg/dL higher blood Pb concentration whi...Continue Reading

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Citations

Jul 13, 2017·Environmental Science and Pollution Research International·Juan Mateo AnchordoquyCecilia C Furnus
Jul 21, 2020·Reproductive Medicine and Biology·Fumitoshi KogaToru Mizoguchi
Jun 18, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Liming ZhouJie Li
Sep 2, 2021·Environmental Science and Pollution Research International·Abeer Abdulrahman BanjabiSaid Salama Moselhy

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