Heavy prenatal alcohol exposure and increased risk of stillbirth

BJOG : an International Journal of Obstetrics and Gynaecology
Colleen M O'LearyCarol Bower

Abstract

To investigate the association between heavy prenatal alcohol exposure and stillbirth. Data linkage cohort study. Western Australia (WA). The exposed cohort included mothers with an alcohol-related diagnosis (International Classification of Diseases, ninth/tenth revisions) recorded in health data sets and all their offspring born in WA (1983-2007). Mothers without an alcohol-related diagnosis and their offspring comprised the comparison cohort. Exposed and comparison mothers were identified through the WA Data Linkage System. Odds ratios for stillbirth at 20+ weeks of gestation were estimated by logistic regression, stratified by Aboriginal status. The proportion of stillbirths at 20+ weeks of gestation is presented per 1000 births, as well as adjusted odds ratios (aOR) and 95% confidence intervals (95% CI), and population-attributable fractions. Increased odds of stillbirth were observed for mothers with an alcohol-related diagnosis at any stage of their life for both non-Aboriginal (aOR 1.36; 95% CI 1.05-1.76) and Aboriginal (aOR 1.33; 95% CI 1.08-1.64) births. When an alcohol diagnosis was recorded during pregnancy, increased odds were observed for non-Aboriginal births (aOR 2.24; 95% CI 1.09-4.60), with the highest odds of ...Continue Reading

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Citations

Feb 20, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·C M O'LearyC Bower
Jul 23, 2013·Birth Defects Research. Part A, Clinical and Molecular Teratology·Colleen M O'LearyCarol Bower
Aug 20, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·V M Srikartika, Cm O'Leary
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