HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticity.

Clinical & Developmental Immunology
Marsela Braunstein, Michele K Anderson

Abstract

The development of T cells from multipotent progenitors in the thymus occurs by cascades of interactions between signaling molecules and transcription factors, resulting in the loss of alternative lineage potential and the acquisition of the T-cell functional identity. These processes require Notch signaling and the activity of GATA3, TCF1, Bcl11b, and the E-proteins HEB and E2A. We have shown that HEB factors are required to inhibit the thymic NK cell fate and that HEBAlt allows the passage of T-cell precursors from the DN to DP stage but is insufficient for suppression of the NK cell lineage choice. HEB factors are also required to enforce the death of cells that have not rearranged their TCR genes. The synergistic interactions between Notch1, HEBAlt, HEBCan, GATA3, and TCF1 are presented in a gene network model, and the influence of thymic stromal architecture on lineage choice in the thymus is discussed.

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Citations

Jan 30, 2014·Annual Review of Immunology·Ellen V Rothenberg
Aug 16, 2014·Immunological Reviews·Subhash K Tripathi, Riitta Lahesmaa
Mar 12, 2013·Advances in Hematology·Amanda J Moore, Michele K Anderson
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Jul 14, 2017·Leukemia·C MeyerR Marschalek
Mar 19, 2021·Journal of Biological Physics·Jianting YeRuiqi Wang

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Methods Mentioned

BETA
ubiquitination
gene
transgenic

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