Hedgehog can drive terminal differentiation of amniote slow skeletal muscle

BMC Developmental Biology
Xiaopeng LiSimon M Hughes

Abstract

Secreted Hedgehog (Hh) signalling molecules have profound influences on many developing and regenerating tissues. Yet in most vertebrate tissues it is unclear which Hh-responses are the direct result of Hh action on a particular cell type because Hhs frequently elicit secondary signals. In developing skeletal muscle, Hhs promote slow myogenesis in zebrafish and are involved in specification of medial muscle cells in amniote somites. However, the extent to which non-myogenic cells, myoblasts or differentiating myocytes are direct or indirect targets of Hh signalling is not known. We show that Sonic hedgehog (Shh) can act directly on cultured C2 myoblasts, driving Gli1 expression, myogenin up-regulation and terminal differentiation, even in the presence of growth factors that normally prevent differentiation. Distinct myoblasts respond differently to Shh: in some slow myosin expression is increased, whereas in others Shh simply enhances terminal differentiation. Exposure of chick wing bud cells to Shh in culture increases numbers of both muscle and non-muscle cells, yet simultaneously enhances differentiation of myoblasts. The small proportion of differentiated muscle cells expressing definitive slow myosin can be doubled by Shh....Continue Reading

References

Mar 30, 1977·Anatomy and Embryology·B ChristM Jacob
Apr 1, 1990·Developmental Biology·K CondonW J Thompson
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J B Miller, F E Stockdale
Dec 1, 1986·The Journal of Cell Biology·J B Miller, F E Stockdale
Jan 1, 1972·The Journal of Cell Biology·M C O'Neill, F E Stockdale
Jul 1, 1981·The Journal of Cell Biology·N A Rubinstein, A M Kelly
Sep 26, 1997·Genes & Development·C S BlagdenS M Hughes
Nov 14, 1997·Developmental Biology·C M FanM Tessier-Lavigne
Mar 7, 1998·Developmental Biology·J CapdevilaR L Johnson
Jun 23, 1998·Current Biology : CB·H AmthorK Patel
Jul 4, 1998·Mechanisms of Development·N KahaneC Kalcheim
Mar 11, 1999·Current Opinion in Neurobiology·S M Hughes, P C Salinas
Apr 13, 1999·Cell and Tissue Research·C KalcheimN Kahane
Jun 30, 2000·Biochemical and Biophysical Research Communications·S BayolC Brownson
Nov 7, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H L StickneyS H Devoto
Nov 7, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·F E StockdaleB Christ
Sep 22, 2001·Current Biology : CB·M J BarresiS H Devoto
Dec 4, 2001·Genes & Development·P W Ingham, A P McMahon
Feb 1, 2002·Developmental Biology·Yvette Bren-Mattison, Bradley B Olwin
Jul 27, 2002·Annual Review of Cell and Developmental Biology·Mary Elizabeth PownallCharles P Emerson

❮ Previous
Next ❯

Citations

Nov 21, 2008·Proceedings of the National Academy of Sciences of the United States of America·Juan P HenriquezPatricia C Salinas
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Min Lu, Robert S Krauss
Dec 26, 2012·The Journal of Biological Chemistry·Anastassia VoronovaIlona S Skerjanc
Sep 19, 2012·Genes & Development·Jimmy Kuang-Hsien HuClifford J Tabin
Sep 19, 2012·Genes & Development·Claire AndersonAnne-Gaëlle Borycki
Mar 19, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Seymour GruffermanHarold M Maurer
Jan 4, 2007·BMC Developmental Biology·Yau-Hung ChenHuai-Jen Tsai
Jun 14, 2014·Proceedings of the National Academy of Sciences of the United States of America·Wenxiang FuBrian David Dynlacht
Nov 23, 2010·AJNR. American Journal of Neuroradiology·M D DobbsS P Donahue
Aug 23, 2006·The Journal of Cell Biology·Hak Kyun KimAnindya Dutta
Jun 1, 2005·Cancer Letters·Simonetta Pazzaglia
Oct 19, 2006·Developmental Biology·Xuesong FengStephen H Devoto
Dec 25, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Gi Fay Mok, Dylan Sweetman
Mar 13, 2009·Organogenesis·Charlotte A Maltin
Jun 13, 2019·Journal of Cellular Physiology·Caleb S HayesDavid S Waddell
Apr 16, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nobuko Hagiwara
Mar 21, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shalini V Mohan, Anne Lynn S Chang
Jan 10, 2006·Cell Metabolism·Jae Myoung SuhJonathan M Graff
Dec 15, 2010·Developmental Biology·Daniel P S OsbornSimon M Hughes
Sep 3, 2011·Developmental Biology·Anne-Françoise RichardPascal Maire

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis