Hedgehog Signaling in Lung Cancer: From Oncogenesis to Cancer Treatment Resistance

International Journal of Molecular Sciences
Etienne Giroux-LeprieurBiao He

Abstract

Hedgehog signaling pathway is physiologically activated during embryogenesis, especially in lung development. It is also reactivated in many solid tumors. In lung cancer, Hedgehog pathway is closely associated with cancer stem cells (CSCs). Recent works have shown that CSCs produced a full-length Sonic Hedgehog (Shh) protein, with paracrine activity and induction of tumor development. Hedgehog pathway is also involved in tumor drug resistance in lung cancer, as cytotoxic chemotherapy, radiotherapy, and targeted therapies. This review proposes to describe the activation mechanisms of Hedgehog pathway in lung cancer, the clinical implications for overcoming drug resistance, and the perspectives for further research.

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Citations

Jul 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rommy TeranJorge Heredia-Moya
Sep 14, 2019·International Journal of Molecular Sciences·Siyuan ZengHai Yang
Mar 1, 2020·Cells·Frédéric LézotFranck Verrecchia
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Oct 30, 2021·Pharmaceutical Biology·Piao ZhouJing Guo

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Methods Mentioned

BETA
xenograft
xenografts
X-ray

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