Hedgehog signaling regulates segment formation in the annelid Platynereis.

Science
Nicolas DrayGuillaume Balavoine

Abstract

Annelids and arthropods share a similar segmented organization of the body whose evolutionary origin remains unclear. The Hedgehog signaling pathway, prominent in arthropod embryonic segment patterning, has not been shown to have a similar function outside arthropods. We show that the ligand Hedgehog, the receptor Patched, and the transcription factor Gli are all expressed in striped patterns before the morphological appearance of segments in the annelid Platynereis dumerilii. Treatments with small molecules antagonistic to Hedgehog signaling disrupt segment formation. Platynereis Hedgehog is not necessary to establish early segment patterns but is required to maintain them. The molecular similarity of segment patterning functions of the Hedgehog pathway in an annelid and in arthropods supports a common origin of segmentation in protostomes.

References

Aug 1, 1994·Current Opinion in Genetics & Development·S DiNardoP H O'Farrell
Oct 5, 2001·Trends in Genetics : TIG·V Hatini, S DiNardo
Oct 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·James K ChenPhilip A Beachy
Nov 5, 2002·Genes & Development·James K ChenPhilip A Beachy
Mar 7, 2003·Development·Dongmin KangDavid A Weisblat
Sep 15, 2004·Development Genes and Evolution·Franck SimonnetEric Quéinnec
Feb 14, 2006·Science·Eric H Davidson, Douglas H Erwin
Feb 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Patrick R H SteinmetzDetlev Arendt
May 9, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Scott A Holley
Apr 9, 2008·Development Genes and Evolution·Laila Farzana, Susan J Brown
Jan 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Matthias PechmannWim G M Damen

❮ Previous
Next ❯

Citations

Sep 6, 2011·Development Genes and Evolution·Nick Riddiford, Peter D Olson
Jul 6, 2011·Molecular Biology and Evolution·Jerome H L HuiDavid E K Ferrier
Mar 10, 2012·Science·Andres F SarrazinMichalis Averof
Nov 6, 2010·BMC Evolutionary Biology·Georg MayerLeonie M Quinn
Jan 22, 2011·BMC Biology·David E K Ferrier
Jan 5, 2011·Frontiers in Zoology·Antje Hl FischerDetlev Arendt
Oct 3, 2013·PloS One·Vinoth Babu Veedin-RajanKristin Tessmar-Raible
Jan 1, 2012·Scientifica·Ellen Robertshaw, Clemens Kiecker
May 9, 2014·Genetics·Juliane ZantkeKristin Tessmar-Raible
Jun 8, 2014·Integrative and Comparative Biology·Antje H L FischerJoel Smith
Aug 5, 2014·Zoological Science·Norio MiyamotoYoshihiro Fujiwara
Nov 30, 2013·General and Comparative Endocrinology·Anika K LidkeNicole Rebscher
Apr 20, 2011·Nature Reviews. Genetics·Philip W InghamClaudia Seger
Jan 8, 2011·Evolution & Development·Patrick R H SteinmetzDetlev Arendt
Jan 22, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Kristin Tessmar-RaibleEnrique Arboleda
Nov 15, 2012·Current Opinion in Genetics & Development·David L Richmond, Andrew C Oates
Apr 24, 2013·Developmental Biology·Nao NiwaShigeo Hayashi
Apr 17, 2015·BMC Evolutionary Biology·Viktor V StarunovGuillaume Balavoine
Apr 14, 2015·Nature Biotechnology·Kaia AchimJohn C Marioni
Sep 13, 2014·Science·Antonella LauriDetlev Arendt
Apr 24, 2015·Nature·Nicholas D HollandPeter W H Holland
Feb 27, 2014·Marine Genomics·Paola OliveriAngela Falciatore
Sep 27, 2014·Cell·Maria Antonietta ToschesDetlev Arendt
Dec 14, 2011·Developmental Biology·Jia L SongGary M Wessel
Aug 10, 2016·Current Opinion in Genetics & Development·B Duygu Özpolat, Alexandra E Bely
Nov 18, 2005·Insect Biochemistry and Molecular Biology·Rodrigo A VelardeHugh M Robertson
Oct 12, 2016·Arthropod Structure & Development·Ralf Janssen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.