Hedgehog Signaling Regulates the Ciliary Transport of Odorant Receptors in Drosophila

Cell Reports
Gonzalo M SanchezMattias Alenius

Abstract

Hedgehog (Hh) signaling is a key regulatory pathway during development and also has a functional role in mature neurons. Here, we show that Hh signaling regulates the odor response in adult Drosophila olfactory sensory neurons (OSNs). We demonstrate that this is achieved by regulating odorant receptor (OR) transport to and within the primary cilium in OSN neurons. Regulation relies on ciliary localization of the Hh signal transducer Smoothened (Smo). We further demonstrate that the Hh- and Smo-dependent regulation of the kinesin-like protein Cos2 acts in parallel to the intraflagellar transport system (IFT) to localize ORs within the cilium compartment. These findings expand our knowledge of Hh signaling to encompass chemosensory modulation and receptor trafficking.

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Citations

Jul 13, 2017·Nature Reviews. Molecular Cell Biology·Jeremy F Reiter, Michel R Leroux
Jan 21, 2018·The Journal of Cell Biology·Yang YueKristen J Verhey
Nov 17, 2017·Journal of Cell Science·Sascha WernerMónica Bettencourt-Dias
Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Devendra Kumar MauryaMattias Alenius
Apr 21, 2018·Frontiers in Cellular Neuroscience·Dieter Wicher
Sep 15, 2018·Frontiers in Cellular Neuroscience·Carolina Gomez-DiazEsther Alcorta
Oct 7, 2020·Open Biology·Hayden R Schmidt, Richard Benton
Jan 28, 2021·Cell and Tissue Research·Dieter Wicher, Fabio Miazzi
Jan 26, 2021·Cell and Tissue Research·Shadi Jafari, Mattias Alenius

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