Hedgehog signalling controls zebrafish neural keel morphogenesis via its level-dependent effects on neurogenesis

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Masanari Takamiya, Jose A Campos-Ortega

Abstract

We investigated the role of hedgehog (Hh) signalling on zebrafish neurulation, focusing on the intimate relationship between neurogenesis and morphogenesis during the neural keel stage. Through the analyses of Hh loss- and gain-of-function phenotypes, we found that Hh signalling controls the neural keel morphogenesis. To investigate underlying mechanisms, we examined cellular elongation polarity in the neural keel of Hh loss- and gain-of-function phenotypes and compared this with the deficient phenotype of a planar cell polarity (PCP) molecule, Trilobite/Strabismus. We found that Hh signalling controls cell elongation polarity of the neuroepithelium at least in part by means of PCP pathway; however, its effects are not strong enough per se to affect keel morphogenesis; instead Hh signalling mainly controls keel morphogenesis by means of affecting both medial and lateral neurogenesis. We devised a method for precise evaluation of neurogenesis in loss- and gain-of-Hh phenotypes that compensates for its delay caused by disturbed morphogenesis. We present a model that Hh signalling exerts level-dependent and binary-opposite effects on medial neurogenesis, whose modification to explain lateral neurogenesis reveals regional differenc...Continue Reading

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Citations

May 19, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Steve M NelsonDeborah L Stenkamp
Jun 11, 2009·Seminars in Cell & Developmental Biology·Padmashree C G Rida, Ping Chen
Oct 26, 2018·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yen-Che HsiehYi-Chuan Cheng
Mar 5, 2015·Scientific Reports·Pierre AffaticatiPhilippe Vernier

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