Sep 5, 2008

Height and prostate cancer risk: a large nested case-control study (ProtecT) and meta-analysis

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Luisa ZuccoloR M Martin

Abstract

Height, a marker of childhood environmental exposures, is positively associated with prostate cancer risk, perhaps through the insulin-like growth factor system. We investigated the relationship of prostate cancer with height and its components (leg and trunk length) in a nested case-control study and with height in a dose-response meta-analysis. We nested a case-control study within a population-based randomized controlled trial evaluating treatments for localized prostate cancer in British men ages 50 to 69 years, including 1,357 cases detected through prostate-specific antigen testing and 7,990 controls (matched on age, general practice, assessment date). Nine bibliographic databases were searched systematically for studies on the height-prostate cancer association that were pooled in a meta-analysis. Based on the nested case-control, the odds ratio (OR) of prostate-specific antigen-detected prostate cancer per 10 cm increase in height was 1.06 [95% confidence interval (95% CI): 0.97-1.16; p(trend) = 0.2]. There was stronger evidence of an association of height with high-grade prostate cancer (OR: 1.23; 95% CI: 1.06-1.43), mainly due to the leg component, but not with low-grade disease (OR: 0.99; 95% CI: 0.90-1.10). In gener...Continue Reading

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Citations

Mentioned in this Paper

Prostatic Neoplasms
KLK3 gene
Meta-Analysis (Publications)
Randomized Controlled Trial (Publication)
Somatomedins
Family Medicine (Field)
Prostate Carcinoma
Prostate Cancer, Familial
Insulin-like Growth Factor Activity
Nested Case-Control Studies

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