Heightened affective response to perturbation of respiratory but not pain signals in eating, mood, and anxiety disorders

PloS One
Rachel C LapidusTulsa 1000 Investigators

Abstract

Several studies have recently suggested that an abnormal processing of respiratory interoceptive and nociceptive (painful) stimuli may contribute to eating disorder (ED) pathophysiology. Mood and anxiety disorders (MA) are also characterized by abnormal respiratory symptoms, and show substantial comorbidity with ED. However, no studies have examined both respiratory and pain processing simultaneously within ED and MA. The present study systematically evaluated responses to perturbations of respiratory and nociceptive signals across the levels of physiology, behavior, and symptom report in a transdiagnostic ED sample (n = 51) that was individually matched to MA individuals (n = 51) and healthy comparisons (HC; n = 51). Participants underwent an inspiratory breath-holding challenge as a probe of respiratory interoception and a cold pressor challenge as a probe of pain processing. We expected both clinical groups to report greater stress and fear in response to respiratory and nociceptive perturbation than HCs, in the absence of differential physiological and behavioral responses. During breath-holding, both the ED and MA groups reported significantly more stress, feelings of suffocation, and suffocation fear than HC, with the ED ...Continue Reading

References

Sep 1, 1992·Biological Psychiatry·P L FarisJ E Mitchell
Jun 1, 1991·Biological Psychiatry·S LautenbacherJ C Krieg
Mar 14, 1995·Journal of Affective Disorders·G PernaM Gasperini
Sep 1, 1993·Journal of Psychosomatic Research·J C KriegS Lautenbacher
Jul 1, 1996·Journal of Psychosomatic Research·M de ZwaanG Stacher
Jun 16, 1997·Psychiatry Research·D CaldirolaL Bellodi
Aug 1, 1997·Behaviour Research and Therapy·A J Willem Van der Does
Mar 21, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K L KochR M Stern
Apr 7, 1999·The International Journal of Eating Disorders·K H Luce, J H Crowther
Dec 3, 1999·BMJ : British Medical Journal·J F MorganJ H Lacey
Sep 15, 2001·Journal of General Internal Medicine·K KroenkeJ B Williams
Apr 11, 2003·Psychiatry Research·Nathalie T GodartJacques Fermanian
Sep 2, 2003·The International Journal of Eating Disorders·Daniel SteinRhadika Rao
Mar 31, 2004·Psychiatry Research·Giampaolo PernaLaura Bellodi
Dec 1, 2004·The American Journal of Psychiatry·Walter H KayeKim Masters
Feb 24, 2005·Psychological Medicine·Kelly L KlumpWalter H Kaye
Aug 3, 2005·Pain·Karl-Jürgen BärHeinrich Sauer
Oct 29, 2005·The International Journal of Eating Disorders·Guido K FrankWalter H Kaye
May 12, 2006·Depression and Anxiety·Sonya B NormanMurray B Stein
May 25, 2006·Current Opinion in Psychiatry·James E Mitchell, Scott Crow
Jun 2, 2006·Psychosomatic Medicine·Barton J BlinderVisant A Sanathara
Aug 24, 2006·Journal of the American Academy of Child and Adolescent Psychiatry·Karl-Jürgen BärHeinrich Sauer
Sep 8, 2006·Journal of Psychiatric Research·Norman B SchmidtJon K Maner
Jun 15, 2007·Psychological Assessment·Steven TaylorSamuel Jurado Cardenas
Dec 7, 2007·The American Journal of Psychiatry·Angela WagnerWalter H Kaye
Jul 16, 2009·Nature Reviews. Neuroscience·Walter H KayeMartin Paulus
Jul 30, 2009·Clinical Psychology & Psychotherapy·Graham C L Davey, Laura Chapman
Sep 16, 2009·Clinical Psychology Review·Katharina DomschkeAlexander L Gerlach
Nov 4, 2009·Psychological Bulletin·Bunmi O Olatunji, Kate B Wolitzky-Taylor
Dec 1, 2009·The Journal of Pain : Official Journal of the American Pain Society·Christiane SchwierKarl-Jürgen Bär
Mar 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Christian SchmahlMartin Bohus
Mar 26, 2010·Depression and Anxiety·Kendra L S OcañezMichael W Otto
May 22, 2010·Brain Structure & Function·Martin P Paulus, Murray B Stein
Jun 24, 2010·Appetite·Joanna E SteinglassB Timothy Walsh
Sep 8, 2010·Clinical Psychology Review·Paul E JenkinsJacqueline M Blissett
Nov 27, 2010·Journal of Affective Disorders·David MischoulonDavid B Herzog
Jul 1, 2011·Biological Psychiatry·Felicity A CowdreyCiara McCabe

❮ Previous
Next ❯

Citations

Jan 16, 2021·The International Journal of Eating Disorders·Tiffany A BrownChristina E Wierenga
May 1, 2021·International Journal of Environmental Research and Public Health·Andrea PoliMario Miccoli
Aug 7, 2021·Neuroscience and Biobehavioral Reviews·Rebecca BrewerGeoffrey Bird

❮ Previous
Next ❯

Software Mentioned

R

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.