PMID: 7147611Sep 1, 1982Paper

Heinz body anemia and methemoglobinemia in ponies given red maple (acer rubrum L.) leaves

Veterinary Pathology
L W GeorgeM J Suarez

Abstract

Ponies given dried red maple (Acer rubrum L.) leaves at a dose of 3.0 gm/kg body weight became ill and died one to five days after administration of the leaves. Two clinical patterns of disease were seen. Ponies given dried leaves collected after September 15 died by 18 hours, while ponies given dried leaves collected before September 15 became ill with a hemolytic syndrome and died by three to five days. Freshly harvested leaves administered immediately after collection did not produce disease in ponies, but when dried, they became toxic and remained so for at least 30 days. Overnight freezing did not alter the toxicity of the leaves. Leaves were toxic when administered at doses of 1.5 gm/kg of body weight. The clinical signs of ponies with the hemolytic syndrome included polypnea, tachycardia, icterus, cyanosis, scleral petechiation, and brownish discoloration of the urine and blood. Blood changes of ponies with the hemolytic syndrome included anemia, hemoglobinemia, Heinz bodies, depletion of erythrocyte reduced glutathione, increased erythrocyte fragility, and increased serum levels of aspartate amino transferase, sorbitol dehydrogenase, plasma protein, and bilirubin. Lesions of ponies that died from the hemolytic syndrome ...Continue Reading

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Citations

Jan 1, 1994·Veterinary Clinical Pathology·William J. ReaganJohn Turek
Jan 27, 2015·Journal of Veterinary Internal Medicine·R BozorgmaneshE D Voss
Jun 4, 2015·The Veterinary Clinics of North America. Equine Practice·Ahmad Al-Dissi
May 3, 2016·Journal of Ethnopharmacology·Wu BiPeigen Xiao
Jun 17, 2016·Journal of the American Veterinary Medical Association·Marigold E ErnstWilliam F Gilsenan
Dec 18, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Karan AgrawalKaryn Bischoff
Sep 18, 2014·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Kyla M WalterBirgit Puschner
Apr 10, 2002·American Journal of Veterinary Research·Jeanelle D BoyerDan L Brown
Sep 4, 2004·Journal of the American Veterinary Medical Association·Shane F DewittMelissa R Mazan

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