PMID: 6539162Jul 15, 1984Paper

HeLa cell tumor response to 60Co, Cs-137, Cf-252 radiations and cisplatin chemotherapy in nude mice

Cancer
Y MaruyamaJ L Beach

Abstract

HeLa cells were implanted into athymic nude mice from tissue culture and solid tumors established (HeLa cell tumor or HCT). Large cell numbers of 1 X 10(7) were required to obtain consistent and progressive growth, and tumor growth followed a Gompertzian mode. Irradiation studies were carried out using acute Cobalt-60 (60Co), low-dose-rate (LDR) Cs-137 and LDR Cf-252. Cf-252, a neutron-emitting radioisotope, produced an immediate tumor shrinkage and regression response after a dose of 279 cGy. Acute 60Co or LDR Cs-137 irradiation with 1000 cGy had little effect on the HCT. After a dose of 2000 cGy of 60Co radiation tumor shrinkage followed a latent period of approximately 5 days. Cisplatin had no effect on the HCT in nude mice in stationary or late exponential growth.

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Citations

Jan 1, 1989·Cancer Chemotherapy and Pharmacology·M M Tomayko, C P Reynolds
Jan 1, 1996·Cancer Chemotherapy and Pharmacology·J I ZwickerC P Reynolds
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·V Band, R Sager
Mar 26, 2011·International Journal of Radiation Oncology, Biology, Physics·Xin LeiDong Wang
Nov 1, 1985·International Journal of Radiation Oncology, Biology, Physics·Y MaruyamaJ L Beach

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