Helical flow as fluid dynamic signature for atherogenesis risk in aortocoronary bypass. A numeric study

Journal of Biomechanics
Umberto MorbiducciAlberto Redaelli

Abstract

The main purpose of the study was to verify if helical flow, widely observed in several vessels, might be a signature of the blood dynamics of vein graft anastomosis. We investigated the existence of a relationship between helical flow structures and vascular wall indexes of atherogenesis in aortocoronary bypass models with different geometric features. In particular, we checked for the existence of a relationship between the degree of helical motion and the magnitude of oscillating shear stress in conventional hand-sewn proximal anastomosis. The study is based on the numerical evaluation of four bypass geometries that are attached to a simplified computer representation of the ascending aorta with different angulations relative to aortic outflow. The finite volume technique was used to simulate realistic graft fluid dynamics, including aortic compliance and proper aortic and graft flow rates. A quantitative method was applied to evaluate the level of helicity in the flow field associated with the four bypass models under investigation. A linear inverse relationship (R = -0.97) was found between the oscillating shear index and the helical flow index for the models under investigation. The results obtained support the hypothesis...Continue Reading

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Citations

Jul 24, 2010·Biomechanics and Modeling in Mechanobiology·Umberto MorbiducciAlberto Redaelli
May 26, 2009·Annals of Biomedical Engineering·Kelvin K L WongDerek Abbott
Dec 25, 2009·Annals of Biomedical Engineering·Xiao LiuXiaoyan Deng
Dec 24, 2011·Medical & Biological Engineering & Computing·Umberto MorbiducciAlberto Redaelli
Nov 20, 2012·Journal of Biomechanics·K Van CanneytP Verdonck
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Oct 16, 2015·Annals of Biomedical Engineering·Efstratios KokkalisJ Graeme Houston
Jan 8, 2016·Thrombosis and Haemostasis·Umberto MorbiducciJolanda J Wentzel
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Aug 3, 2012·Journal of Biomechanics·Diego GalloUmberto Morbiducci
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