Abstract
Linear Accelerator-based Intensity Modulated Radiation Therapy (IMRT), either as step-and shoot (SS) or in dynamic mode, is now considered routine in the definitive management of head and neck squamous cell carcinoma (HNSCC). Helical TomoTherapy (HT) is a new platform to deliver IMRT. This study aims to compare step-and-shoot Intensity Modulated Radiation Therapy (SS IMRT) with dynamic Helical TomoTherapy (HT) dosimetrically in patients with head and neck squamous cell carcinoma (HNSCC). Twelve patients with HNSCC, previously treated with SS IMRT, were re-planned on HT using the same CT dataset. Plans were compared for target coverage and organs-at-risk (OARs) sparing. Sparing of parotids was assessed after stratifying for side (contralateral vs. ipsilateral) and site of disease (laryngopharynx vs. oropharynx). Normal tissue complication probabilities (NTCP) were also compared for the parotid glands. All HT plans showed improvement in target coverage and homogeneity, and reduction in OAR doses as compared to SS IMRT plans. For PTV 66, the mean V 99 improved by 14.65% ( P = 0.02). Dose Homogeneity (D 10-90 ) was significantly better in the HT plans (mean 2.07Gy as compared to 4.5Gy in the SS IMRT plans, P = 0.02). HT resulted in...Continue Reading
References
May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·G J KutcherR Mohan
Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·G J Kutcher, C Burman
Jan 1, 1997·Medical Physics·A Niemierko
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·M A HuntS A Leibel
Jun 8, 2001·International Journal of Radiation Oncology, Biology, Physics·A EisbruchJ A Ship
Dec 4, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vincent GrégoireHervé Reychler
Jun 1, 2005·International Journal of Radiation Oncology, Biology, Physics·Marco van VulpenB Gino Fallone
Mar 21, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Claudio FiorinoRicardo Calandrino
Jun 6, 2006·International Journal of Radiation Oncology, Biology, Physics·Ke ShengPaul W Read
Jan 18, 2008·Physics in Medicine and Biology·V A Semenenko, X A Li
Jun 23, 2009·Journal of Cancer Research and Therapeutics·Vedang MurthyJaiprakash Agarwal
Citations
May 15, 2012·BMC Cancer·Nam P NguyenDave Abraham
May 3, 2013·Radiation Oncology·Stephen Wan Leung, Tsair-Fwu Lee
Apr 5, 2013·PloS One·Nam P NguyenVincent Vinh-Hung
Jan 29, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S TribiusP Tennstedt
Sep 14, 2012·CA: a Cancer Journal for Clinicians·Joel B EpsteinEllie Maghami
Apr 9, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·N KramkimelY M Kirova
Sep 17, 2013·Head & Neck·Israël FortinPhuc Felix Nguyen-Tan
Aug 21, 2013·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Stéphanie Servagi VernatPhilippe Giraud
Jul 5, 2011·Oral Oncology·Nam P NguyenVincent Vinh-Hung
Jul 10, 2013·Journal of Applied Clinical Medical Physics·Ashleigh WeyhDanielle Lack
May 31, 2017·The British Journal of Radiology·Malgorzata SkorskaAdam Ryczkowski
May 15, 2018·Head & Neck·Laura B MoroneyBrett G M Hughes
Nov 6, 2010·Anti-cancer Drugs·Juliette ThariatPascal Pommier
Oct 9, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Timur KocaAysen Aydin
Jun 1, 2013·The Oncologist·Dirk Van GestelVincent Gregoire
Jul 4, 2018·BioMed Research International·Shan LiXin-Qiong Huang
Nov 3, 2017·Scientific Reports·Yujin XuMing Chen