Helical tomotherapy of nasopharyngeal carcinoma-any advantages over conventional intensity-modulated radiotherapy?

Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists
W C Vincent WuWing-ki W Fung

Abstract

Helical tomotherapy uses different planning algorithm and dose delivery method from the linear accelerator (linac)-based intensity-modulated radiotherapy (IMRT). This study compared the dosimetric outcomes between the tomotherapy plans and conventional linac-based IMRT plans in the treatment of nasopharyngeal carcinoma (NPC). Fifteen stage II-III cancer (American Joint Committee on Cancer) NPC patients treated by tomotherapy were conveniently recruited. Apart from the tomotherapy plans, a 7-field 6-MV photon conventional IMRT plan was computed for each patient with the same CT dataset and reference from the dose constraints and target dose prescriptions of the tomotherapy plans using the XiO treatment planning system. Average values of the dose parameters including the conformity index (CI), homogeneity index (HI), maximum and minimum doses of the target volumes, and the maximum and mean doses of the organs at risk (OAR) were compared between the two treatment methods. Better dose coverage of the planning target volume (PTV) was demonstrated in the tomotherapy plans, in which the differences in the maximum and mean doses reached statistical significance (p < 0.05). Besides, the CI of the tomotherapy plans were significantly hig...Continue Reading

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Citations

Dec 11, 2013·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Francis Kar-ho LeeRoger Kai-cheong Ngan
Mar 17, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Song QuXiao-Dong Zhu

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